Orodispersible tablets: A comprehensive review.
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Date
2013-02
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Abstract
Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method
of drug delivery resulting in highest patient compliance. Oral delivery of active ingredients include a number of technologies, many of which may be classified as
Orodispersible tablets (ODTs). Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and
suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an
unavailability of water, swallowing conventional tablets may be difficult. ODTs systems may offer a solution for these problems. Advancements in the technology
arena for manufacturing these systems includes the use of freeze drying, cotton candy, melt extrusion, sublimation, direct compression besides the classical wet
granulation processes. This has encnouraged both academia and industry to generate new orally disintegrating formulations and technological approaches in this
field. This article attempts at discussing the ideal characteristics, advantages and disadvantages, formulation aspects, formulation technologies and future potential
of ODTs.
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Keywords
Dysphagia, Formulation technologies, Orodispersible tablets, Pharmaceutical industry
Citation
Arora Pooja, Sethi Vandana Arora. Orodispersible tablets: A comprehensive review. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Feb-Mar; 2(2): 270-284.