Protective effect of eucalyptus globulus extract on glufosinate ammonium -induced hepatotoxicity in wistar rats

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dc.contributor.authorSharma, Priyankaen_US
dc.contributor.authorPanda, B.Nen_US
dc.contributor.authorRathore, S.Sen_US
dc.contributor.authorAggarwal, M.Len_US
dc.contributor.authorB.Bhaten_US
dc.contributor.authorChacko, K.Men_US
dc.date.accessioned2020-04-23T07:25:54Z
dc.date.available2020-04-23T07:25:54Z
dc.date.issued2018-01
dc.description.abstractThe present study aims to investigate the hepatoprotective effect of Eucalyptus globulus extract against pesticide liver damage in comparison to silymarin, a classical antioxidant liver medicine. Liver damage was induced by oral administration of toxicant i.e. Glufosinate ammonium. The extent of damage was studied by assessing biochemical parameters and histopathological evaluations. The aqueous extracts of Eucalyptus globulus were administered respectively to the animals pretreated with pesticide and its effects on biochemical parameters were compared with standard drug silymarin (100mg/kg b.wt). Eucalyptus globules showed significant reduction of serum enzymes AST, ALT, ALP & Bilirubin (Aspartate Transminase, Alanine Transminase, Alkaline Phosphatase & Total bilirubin) when compared to control counterparts. The hepatoprotective effect of Eucalyptus globules was comparable with the standard drug silymarin and it was confirmed by histopathological findings. Moreover, these effects presented in a dose-dependent manner.The present study showed that aqueous extract of Eucalyptus globulus at the dosage level of 500 mg/kgb.wt may play a protective role against pesticideinduced hepatotoxicityen_US
dc.identifier.affiliationsShriram Institute for Industrial Research, 19 University Road, Delhi-110007 Mewar University, Chittorgarh (Rajasthan)en_US
dc.identifier.citationSharma Priyanka, Panda B.N, Rathore S.S, Aggarwal M.L, B.Bhat, Chacko K.M. Protective effect of eucalyptus globulus extract on glufosinate ammonium -induced hepatotoxicity in wistar rats.. International Journal of Applied Biology and Pharmaceutical Technology. 2018 Jan; 9(1): 24-31en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198202
dc.languageenen_US
dc.publisherInternational Journal of Applied Biology and Pharmaceutical Technologyen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.21276/ijabpten_US
dc.subjectGlufosinate-ammonium (GA)en_US
dc.subjectsilymarinen_US
dc.subjectLiver toxicityen_US
dc.subjectEucalyptus globulusen_US
dc.titleProtective effect of eucalyptus globulus extract on glufosinate ammonium -induced hepatotoxicity in wistar ratsen_US
dc.typeJournal Articleen_US
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