Colon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilization

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dc.contributor.authorThulluru, Ashoken_US
dc.contributor.authorAnuradha, K. C.en_US
dc.contributor.authorkumar, K. Saravanaen_US
dc.contributor.authorNawaz, Mahammeden_US
dc.contributor.authorKumar, Ch. S. Phanien_US
dc.contributor.authorMohan, K. Siva Jaganen_US
dc.date.accessioned2020-09-24T07:34:31Z
dc.date.available2020-09-24T07:34:31Z
dc.date.issued2019-06
dc.description.abstractAlbendazole (AZ) is a drug used for the treatment of gastrointestinal nematode infections. Phase solubility study was performed to investigate the optimized ratio of AZ: β-cyclodextrin (β-CD) solid dispersion (SD). Increase in the solubility of optimized AZ: β-CD SD was further enhanced by addition sodium lauryl sulfate (SLS) in different ratios was studied. Matrix tablets of the optimized ratio of AZ: β-CD SD with SLS and various proportions (10%, 15%, and 20%) of guar gum (GG). xanthan gum (XG) and pectin (PT) were prepared by non-aqueous wet granulation with PVP K30. Standard calibration curve for AZ was performed in three buffers like 0.1 N HCl, pH 6.8 phosphate buffer solution (PBS) and pH 7.4 PBS and absorbance were measured at 295 nm. Tablets were evaluated for various physical characteristics such as thickness, hardness, and drug content uniformity. The matrix tablets were subjected to in vitro drug release studies in 0.1 N HCl (2 h), pH 6.8 PBS (3 h) and pH 7.4 PBS (19 h) with and without rat caecal content medium. Formulation F9 shows 70.65% and 95.62% of AZ in with and without rat caecal content media respectively is selected as optimized one. Optimized formulation F9 passed the test for stability up to 3 months as per ICH guidelines.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy , A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Adarsa College of Pharmacy, G. Kothapalli-533 285, Gokavaram (Md.), E.G. (Dist.), Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy , A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Indiaen_US
dc.identifier.citationThulluru Ashok, Anuradha K. C., kumar K. Saravana, Nawaz Mahammed, Kumar Ch. S. Phani, Mohan K. Siva Jagan. Colon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilization. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Jun; 8(3): 12-19en_US
dc.identifier.issn2282-0238
dc.identifier.issn2393-932X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203820
dc.languageenen_US
dc.publisherSociety for research and Development in Educationen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.21276/IJRDPL.2278-0238.2019.8(3).12-19en_US
dc.subjectAlbendazoleen_US
dc.subject?-Cyclodextrinen_US
dc.subjectsodium lauryl sulfateen_US
dc.subjectguar gum. xanthan gumen_US
dc.subjectpectinen_US
dc.titleColon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilizationen_US
dc.typeJournal Articleen_US
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