Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.

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dc.contributor.authorBanerjee, Sarmisthaen_US
dc.contributor.authorManna, Sugataen_US
dc.contributor.authorMukherjee, Sudeshnaen_US
dc.contributor.authorPal, Debalinaen_US
dc.contributor.authorPanda, Chinmay Kren_US
dc.contributor.authorDas, Suktaen_US
dc.date.accessioned2009-05-27T17:35:29Z
dc.date.available2009-05-27T17:35:29Z
dc.date.issued2006-10-26en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractLung cancer is one of the leading causes of cancer related death in most developed and many developing countries of the world. Due to lack of validated screening methods and poor prognosis, treatment of lung cancer has not improved significantly over the last two decades. Therefore the risk of the disease needs to be minimized by preventive measures. One approach for lung cancer prevention envisages reversal or restriction of precancerous lesions by chemopreventive intervention. It demands a deeper understanding of the pathogenesis of the disease and identification of the ideal point of intervention. In the present investigation, tea components, epigallocatechin gallate (EGCG) and theaflavins (TF) were assessed for their chemopreventive potential when administered in the post initiation phase of lung carcinogenesis in an experimental mouse model. Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia. The observations strongly indicate that both EGCG and TF can influence the expression of these genes to modulate the process of carcinogenesis, resulting in delayed onset and lowered incidence of pre-invasive lung lesions.en_US
dc.description.affiliationDepartment of Oncogene Regulation, Chittarajan National Cancer Institute, Kolkata 700026, India.en_US
dc.identifier.citationBanerjee S, Manna S, Mukherjee S, Pal D, Panda CK, Das S. Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. Asian Pacific Journal of Cancer Prevention. 2006 Oct-Dec; 7(4): 661-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37471
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshBenzopyrenesen_US
dc.subject.meshBiflavonoids --pharmacologyen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCaspase 3 --metabolismen_US
dc.subject.meshCatechin --analogs & derivativesen_US
dc.subject.meshCell Proliferation --drug effectsen_US
dc.subject.meshCyclooxygenase 2 --drug effectsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFlavonoids --pharmacologyen_US
dc.subject.meshLung Neoplasms --chemically induceden_US
dc.subject.meshMiceen_US
dc.subject.meshPhenols --pharmacologyen_US
dc.subject.meshTea --chemistryen_US
dc.titleBlack tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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