Thyrotropin releasing hormone-induced potentiation of spinal monosynaptic reflex in rats in vitro.

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dc.contributor.authorDeshpande, S Ben_US
dc.contributor.authorWarnick, J Een_US
dc.date.accessioned2009-05-28T16:18:37Z
dc.date.available2009-05-28T16:18:37Z
dc.date.issued1993-02-01en_US
dc.description.abstractSuperfusion of thyrotropin-releasing hormone (TRH) in neonatal rat spinal cord in vitro produced dose (0.01-1.00 microM) dependent potentiation of monosynaptic reflex (MSR) which was maximum (44% of control) at 1 microM of TRH. But no ventral root depolarization was observed with TRH (1 microM) although potassium concentration out side ([K+]0) when increased produced a depolarization at the magnitude of 0.2 mV/mM of [K+]0. TRH-induced potentiation of MSR was not altered in spinal cords, obtained from the animals pretreated with 5,7-dihydroxytryptamine or 6-hydroxydopamine. Neither serotonin antagonists (spiperone, ketanserin, cyproheptadine or 3-troponyl-indole-3-carboxylate) nor adrenergic antagonists (phentolamine or haloperidol) could attenuate TRH-induced potentiation. Inhibition of MSR observed in the spinal cord elicited by stimulating the adjacent dorsal root was unaffected by TRH. The results suggest that, TRH potentiates MSR by directly acting on the motoneurons, without involving presynaptic serotonergic or catecholaminergic neuronal systems or the disinhibition of pre- or post-synaptic inhibition in the spinal cord.en_US
dc.description.affiliationDepartment of Physiology, Banaras Hindu University, Varanasi, India.en_US
dc.identifier.citationDeshpande SB, Warnick JE. Thyrotropin releasing hormone-induced potentiation of spinal monosynaptic reflex in rats in vitro. Indian Journal of Experimental Biology. 1993 Feb; 31(2): 112-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63072
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Serotonin --drug effectsen_US
dc.subject.meshReflex, Monosynaptic --drug effectsen_US
dc.subject.meshSpinal Cord --drug effectsen_US
dc.subject.meshThyrotropin-Releasing Hormone --pharmacologyen_US
dc.titleThyrotropin releasing hormone-induced potentiation of spinal monosynaptic reflex in rats in vitro.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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