Low dose and subchronic Aroclor 1254 induced histopathological changes in mice kidney

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dc.contributor.authorRaja, Jalpaen_US
dc.contributor.authorPathak, Shwetaen_US
dc.contributor.authorKundu, Rahulen_US
dc.date.accessioned2020-10-16T08:50:10Z
dc.date.available2020-10-16T08:50:10Z
dc.date.issued2019-05
dc.description.abstractPresent communication reports the low dose and subchronic duration-dependent histopathological changes afterexposure to Aroclor 1254 in the kidney tissue of Swiss albino mice. Polychlorinated biphenyls (PCBs) like Aroclor1254 congeners accumulate in tissues rich in lipids and remain inside for a long time, affecting the functionality of thecells in direct and indirect ways. The most commonly observed effects were skin ailments such as chloracne, rashes,and effects on kidney functions. Animal studies indicated that PCBs could affect the functionality of the kidney,thyroid, immune, and endocrine systems. Separate groups of mice were subjected to a daily oral dose of 0.1 mg/kgbody weight (BW)/day and 1 mg/kg BW/day Aroclor 1254, dissolved in corn oil, for four subacute exposure durations(7, 14, 21, and 28 days). Control groups were received only the corn oil (vehicle). Results revealed mainly exposureduration-dependent histopathological lesions such as dilation of the tubular cells, fragmentation of cytoplasm andloss of nuclear materials, formation of large vacuoles inside the cells, and necrosis even at very low doses of Aroclorintoxication. The present study reports predominantly exposure duration-dependent histopathological effects ofAroclor 1254 in the kidney tissue of mice. The study suggested that the subacute exposure to low doses of Aroclor1254 could cause significant irreparable structural deformities in the renal cells of the kidney tissue. Results alsoshowed that renal tubular cells were more affected showing severe necrosisen_US
dc.identifier.affiliationsDepartment of Biosciences, Saurashtra University, Rajkot, Gujarat, Indiaen_US
dc.identifier.citationRaja Jalpa, Pathak Shweta, Kundu Rahul. Low dose and subchronic Aroclor 1254 induced histopathological changes in mice kidney. Journal of Applied Biology & Biotechnology. 2019 May; 2019 May: 59-62en_US
dc.identifier.issn2455-7005
dc.identifier.issn2347-212X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209813
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org//10.7324/JABB.2019.70311en_US
dc.subjectPolychlorinated biphenylsen_US
dc.subjectAroclor 1254en_US
dc.subjectIn vivo toxicityen_US
dc.subjectHistopathologyen_US
dc.subjectKidneyen_US
dc.subjectMiceen_US
dc.titleLow dose and subchronic Aroclor 1254 induced histopathological changes in mice kidneyen_US
dc.typeJournal Articleen_US
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