Serum transcobalamin II level in a malarial patient with ceftriaxone-induced haemolyic anaemia.

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dc.contributor.authorAreekul, Suvit
dc.contributor.authorCheeramakara, Cheeraratana
dc.contributor.authorPaksanond, Suporn
dc.contributor.authorSongmuaeng, Kriyaporn
dc.contributor.authorWilairatana, Polrat
dc.date.accessioned2012-04-18T04:03:02Z
dc.date.available2012-04-18T04:03:02Z
dc.date.issued1997-10
dc.description.abstractCephalosporins have rarely been reported as the cause of immune haemolytic anaemia (IHA). The case history of a patient who had elevated serum transcobalamin II (TCII) levels due to a ceftriaxone-induced haemloytic anaemia is presented in this study. The patient was admitted because of high fever due to P.falciparum. The fever subsided after treatment with anti-malarial drugs. However, two days later, the fever recurred and ceftriazone was given. On the next day, the patient had haemolysis with haemoglobinuria and renal insufficiency which resolved after withdrawal of the drug. Serum TCII levels were elevated during the haemolytic episode and the period of renal impairment. The mechanisms of increased serum TCII are probably due to the acute haemolysis and nephrotoxicityinduced by ceftriaxone, leading to the impaired catabolism and clearance of TCII. Therefore, intravascular THII survival is prolonged. Resulting in elevated serum TCIIlevels.en_US
dc.identifier.citationAreekul Suvit, Cheeramakara Cheeraratana, Paksanond Suporn, Songmuaeng Kriyaporn, Wilairatana Polrat. Serum transcobalamin II level in a malarial patient with ceftriaxone-induced haemolyic anaemia. Siriraj Medical Journal, 1997 Oct; 49(10): 995-998.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/137731
dc.language.isoenen_US
dc.source.urihttps://www.sirirajmedj.com/content_download.php?content_id=589en_US
dc.subjectSerum transcobalamin II levelen_US
dc.subjectMalarial patienten_US
dc.subjectCeftriaxone-induced haemolyic anaemiaen_US
dc.titleSerum transcobalamin II level in a malarial patient with ceftriaxone-induced haemolyic anaemia.en_US
dc.typeArticleen_US
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