Toxicological Evaluation of Nelumbo Nucifera Fruit Ethanol Extract

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dc.contributor.authorRajput, Muhammad Alien_US
dc.contributor.authorZehra, Tabassumen_US
dc.contributor.authorZafar, Shahiden_US
dc.contributor.authorKumar, Guneshen_US
dc.contributor.authorFizzah, Alien_US
dc.contributor.authorAslam, Nadiaen_US
dc.date.accessioned2020-09-24T07:29:00Z
dc.date.available2020-09-24T07:29:00Z
dc.date.issued2020-03
dc.description.abstractNelumbo nucifera fruit (NNF) is frequently used for the treatment of many diseases in Asian countries withoutproper scientific evidence of its safety. The purpose of this study was to determine the toxicological effects ofNNF. Toxicity study was conducted on 28 male Wister rats weighing 180-230 g that were allocated equally to 4treatment groups; a control and 3 test groups. Parameters assessed were clinical signs, body weight,hematology, blood biochemistry and histopathology after administration of NNF to rats for 13 weeks. No majortoxicity was revealed throughout the study, though some biochemical changes were observed in hepatic andrenal tissues but these changes did not correspond with histopathology findings. There was no mortality andevidence of systemic toxicity following 13 weeks administration of NNF. Hematology and blood biochemistrydid not reveal any toxicity at any dose; however, histopathological evaluation of hepatic tissues of few animalstreated with 200 mg/kg showed areas of necrosis at lesser extent in few animals after 13 weeks exposure of fruit.Histopathology of renal tissues of group treated with 200 mg/kg revealed areas of moderate tubular disruptionand few foci of tubular necrosis. Although only few adverse effects were observed but NNF administration ifnecessary for a prolonged period, then it may be used in a dose rage of 50-100 mg/kg in order to avoidintractable effects. Additional studies are required to clinically evaluate the safety profile of NNF.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Multan Medical & Dental College, Multan, Pakistan.en_US
dc.identifier.affiliationsDepartment of Pharmacology, University of Health Sciences, Lahore, Pakistan.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Liaquat National Medical College, Karachi, Pakistan.en_US
dc.identifier.affiliationsDepartment of Pathology, Liaquat College of Medicine & Dentistry, Karachi, Pakistan.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Liaquat University of Medical & Health Sciences, Jamshoro, Sindh, Pakistan.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Liaquat National Medical College, Karachi, Pakistan.en_US
dc.identifier.affiliationsDepartment of Forensic Medicine, Liaquat University of Medical & Health Sciences, Jamshoro, Sindh,Pakistan.en_US
dc.identifier.citationRajput Muhammad Ali, Zehra Tabassum, Zafar Shahid, Kumar Gunesh, Fizzah Ali, Aslam Nadia. Toxicological Evaluation of Nelumbo Nucifera Fruit Ethanol Extract. International Journal of Medical Research Professionals. ; : 87-96en_US
dc.identifier.issn2277-3657
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203756
dc.languageenen_US
dc.publisherInternational Journal of Pharmaceutical Research and Allied Sciencesen_US
dc.source.urihttps://ijpras.com/storage/models/article/dwqRtImU670Rr6opnpR1hP2OqrCx6ICE7nDgKTTzkLKVCRR4siqkyVeIrIIp/toxicological-evaluation-of-nelumbo-nucifera-fruit-ethanol-extract.pdfen_US
dc.subjectNelumbo nuciferaen_US
dc.subjecthematologyen_US
dc.subjectbiochemicalen_US
dc.subjecthistopathologicalen_US
dc.subjecttubular necrosisen_US
dc.subjecttoxicity.en_US
dc.titleToxicological Evaluation of Nelumbo Nucifera Fruit Ethanol Extracten_US
dc.typeJournal Articleen_US
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