Serum and tissue markers in primary breast cancer.
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Date
1998-01
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Abstract
Thirty-three primary breast cancers were analyzed for prognostic markers, Immunohistochemical assay of c-erbB-2 oncoprotein was performed in formalin fixed paraffin-embedded tissue. Enzyme immunoassay and radioreceptor assay for ER and PR were respectively done in tumor cytosol. Pre-opertive blood sample obtained from this group of patients were analyzed for CEA, CA15-3 and MCA levels. About 54% of tumor had c-erbB-2 positive staining. Direct association was observed between tumor size, pathological stage, serum CEA levels and c-erbB-2 expression. No significant association existed between the expression of c-erbB-2 and lymph node invasion, histological type, ER and PR status, serum CA15-3 or MCA levels. Increased incidence of c-erbB-2 overexpression among breast cancer patients with large tumor, more advanced stage and elevated CEA level suggests its value for indicating of greater tumor aggressiveness.
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Keywords
Tissue markers, Primary breast cancer
Citation
Chearskul Supornpim, Chariyalertsak Sunanta, Bhothisuwan Kris, Ornsri Pranee, Ornrhebroi Samarn, Churintrapun Malika. Serum and tissue markers in primary breast cancer. Siriraj Medical Journal, 1998 Jan; 50(1): 94-99.