Stability Indicating Simultaneous Equation Method for Determination of Domperidone and (S)-Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer.

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dc.contributor.authorSingh, Sunil
dc.contributor.authorRai, Jyoti
dc.contributor.authorInamullah
dc.contributor.authorChoudhary, Nisha
dc.contributor.authorGautam, Hemendra
dc.contributor.authorSharma, Surabhi
dc.contributor.authorYadav, Ajit Kumar
dc.contributor.authorAgrawal, Vipin Kumar
dc.contributor.authorChaturvedi, Shashank
dc.date.accessioned2015-09-07T08:08:31Z
dc.date.available2015-09-07T08:08:31Z
dc.date.issued2013-07
dc.description.abstractAims: Stability indicating simultaneous equation method for determination of Domperidone and Esomeprazole Magnesium in capsule dosage form using UVSpectrophotometry. Study Design: A new simultaneous equation method was developed and validated for the determination of esomeprazole magnesium and domperidone in capsule dosage form. Place and Duration of Study: Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh during July 2012 to June 2013. Methodology: Simultaneous equation method was performed for estimation of dosage form and degradants. Results: The maximum wavelength (λmax) was found to be 299 nm for esomeprazole magnesium and 287 nm for domperidone. The linearity range was found to be 1-6 μg ml-1 (r2= 0.998) and 5-30 μg ml-1 (r2= 0.999) for esomeprazole magnesium and domperidone, respectively. The value of limit of detection and limit of quantification was 0.116 and 0.386 μgml-1 for esomeprazole magnesium and 0.657 and 2.18 μgml-1 for domperidone, respectively. Forced degradations were carried out under acid, base, thermal, photolytic and oxidative stress conditions. The method was satisfactorily validated as per the ICH guideline. Conclusion: This study shows that the proposed spectrophotometric method is useful for the routine determination of esomeprazole magnesium and domperidone in its combined pharmaceutical dosage form.en_US
dc.identifier.citationSingh Sunil, Rai Jyoti, Inamullah, Choudhary Nisha, Gautam Hemendra, Surabhi Sharma, Yadav Ajit Kumar, Agrawal Vipin Kumar, Chaturvedi Shashank. Stability Indicating Simultaneous Equation Method for Determination of Domperidone and (S)-Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer. British Journal of Pharmaceutical Research. 2013 Jul-Sep; 3(3): 435-445.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163228
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/1311en_US
dc.subjectEsomeprazole magnesiumen_US
dc.subjectdomperidoneen_US
dc.subjectsimultaneous equationen_US
dc.subjectforceden_US
dc.subjectdegradation studiesen_US
dc.subjectvalidationen_US
dc.titleStability Indicating Simultaneous Equation Method for Determination of Domperidone and (S)-Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer.en_US
dc.typeArticleen_US
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