Aflatoxins: An Innocent Cause of Lethality in Humans

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dc.contributor.authorMohammad, Salimen_US
dc.contributor.authorShafikun, Nishaen_US
dc.contributor.authorMohammad, Shahid, Masrooren_US
dc.contributor.authorShagufta, Parweenen_US
dc.date.accessioned2024-09-24T06:47:03Z
dc.date.available2024-09-24T06:47:03Z
dc.date.issued2023-12
dc.description.abstractAccording to Food and Agriculture Organization, United Nations, approximately one-fourth of the world’s food crops are continuously being contaminated comprehensively by mycotoxins. More than 300 types of mycotoxins are produced by one-fourth of the cereal crops infected. The foodstuffs containing aflatoxins are indiscriminately being consumed by people developing various ailments, diseases and even cancer innocently. Aflatoxins (Afs) have been the most widely studied mycotoxin worldwide.The disease caused by the ingestion of aflatoxins is collectively called aflatoxicosis. They are mostly found in peanuts, mouldy maize grains, rice and perishable dairy products. There are four major types of aflatoxins (AFB1, AFB2, AFG1 and AFG2) found in nature mainly produced by the Aspergillus flavus, A. parasiticus and A. nomius. Aflatoxin B1 has always been a potent carcinogen classified by the WHO in Group “A” as causing cancer in humans. It induces mutation in the p53 gene to develop hepatocellular carcinoma (HCC) in humans. This is the third leading cause of cancer deaths worldwide. Keeping view in mind the present paper is an attempt to review the research done so far in the field of aflatoxins in humans. The review focuses on occurrence, epidemiology, historical glimpses, chemical nature and the types of aflatoxins, detection and detoxification, diagnosis, clinical symptoms and the treatment of aflatoxicosis in humans.en_US
dc.identifier.affiliationsSanjay Gandhi Smriti Govt. Autonomous P.G. College, Sidhi, A.P.S. Univ., Bhopal (M.P.), Indiaen_US
dc.identifier.affiliationsSanjay Gandhi Smriti Govt. Autonomous P.G. College, Sidhi, A.P.S. Univ., Bhopal (M.P.), Indiaen_US
dc.identifier.affiliationsPeople’s College of Dental Sciences & Research Center, People’s Univ., Bhopal (M.P.), Indiaen_US
dc.identifier.affiliationsAll India Institute of Medical Sciences (AIMS), Bhopal (M.P.)en_US
dc.identifier.citationMohammad Salim, Shafikun Nisha, Mohammad Shahid Masroor, Shagufta Parween. Aflatoxins: An Innocent Cause of Lethality in Humans. International Journal of Clinical and Biomedical Research. 2023 Oct; 9(4): 1-9en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226861
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://www.sumathipublications.com/index.php/ijcbr/article/view/457/554en_US
dc.subjectAflatoxinsen_US
dc.subjectOccurrenceen_US
dc.subjectDetectionen_US
dc.subjectDetoxificationen_US
dc.subjectAflatoxicosisen_US
dc.subjectHepatocellularen_US
dc.subjectCarcinomaen_US
dc.titleAflatoxins: An Innocent Cause of Lethality in Humansen_US
dc.typeJournal Articleen_US
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