Histological and Immunohistochemical Study of the Beta Cells In Streptozotocin Induced Diabetic Rats Treated with Cynodon Dactylon Aqueous Extract

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dc.contributor.authorJanakiram, Madhan Kumar Soutalluen_US
dc.contributor.authorSugavasi, Rajuen_US
dc.contributor.authorKommanda, Radhakrishna Shettyen_US
dc.contributor.authorGovindarajoo, Parthibanen_US
dc.contributor.authorMani, Muthuvelen_US
dc.date.accessioned2025-05-09T07:25:06Z
dc.date.available2025-05-09T07:25:06Z
dc.date.issued2024-09
dc.description.abstractBackground: Diabetes mellitus is a chronic metabolic disorder that affects human body in terms of physical, psychological and social health. Traditional medicines have been widely used in treatment of diabetes and its complications. After administrating the aqueous extract of Cynodon dactylon in streptozotocin induced diabetic rats, we evaluated the histological and immunohistochemical effects of the ? – cells in the pancreatic islets. Objectives: The objective of the present study is to investigate the antidiabetic effect of Cynodon dactylon aqueous extract in ? – cells of islets, against streptozotocin induced diabetic rats. Materials and Methods: In this study adult male albino rats were used. Aqueous extract of Cynodon dactylon (500 mg/kg.bw/day) administered orally for 45 days. At the end of experimental period, animals were sacrificed, pancreas was isolated and processed for histological and immunohistochemical analysis. Results: The pancreas of Cynodon dactylon aqueous extract treated diabetic rats showed improved islet morphology; and the pancreatic islets of the Cynodon dactylon aqueous extract treated diabetic rats showed consistent elevation in the insulin levels from the ? – cells. Therefore, the antidiabetic activity of Cynodon dactylon aqueous extract might be due to the compounds present in the Cynodon dactylon aqueous extract which stimulate the insulin secretion and protect the intact functional ? – cells from streptozotocin induced destruction. Conclusion: Cynodon dactylon aqueous extract increased the insulin secreting ? – cells in the pancreatic islets and protecting the intact ? – cells from oxidative damage.en_US
dc.identifier.affiliationsAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysiaen_US
dc.identifier.affiliationsSenior Lecturer, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysiaen_US
dc.identifier.affiliationsSenior Lecturer, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysiaen_US
dc.identifier.citationJanakiram Madhan Kumar Soutallu, Sugavasi Raju, Kommanda Radhakrishna Shetty, Govindarajoo Parthiban, Mani Muthuvel . Histological and Immunohistochemical Study of the Beta Cells In Streptozotocin Induced Diabetic Rats Treated with Cynodon Dactylon Aqueous Extract . International Journal of Anatomy and Research. 2024 Sep; 12(3): 8996-9002en_US
dc.identifier.issn2321-4287
dc.identifier.issn2321-8967
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/243185
dc.languageenen_US
dc.publisherIMED Research Publicationsen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.16965/ijar.2024.149en_US
dc.subjectCynodon dactylonen_US
dc.subjectstreptozotocinen_US
dc.subjectPancreatic isletsen_US
dc.subjectoxidative stressen_US
dc.titleHistological and Immunohistochemical Study of the Beta Cells In Streptozotocin Induced Diabetic Rats Treated with Cynodon Dactylon Aqueous Extracten_US
dc.typeJournal Articleen_US
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