Safety Profile of Various 5HT3 Receptor Antagonists Used for PONV Prophylaxis.

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dc.contributor.authorJamwal, Anju
dc.contributor.authorJatindera, Mukta
dc.contributor.authorWakhloo, Renu
dc.contributor.authorKour, Rajdeep
dc.date.accessioned2016-12-06T09:06:46Z
dc.date.available2016-12-06T09:06:46Z
dc.date.issued2016-04
dc.description.abstractThe current study was done to compare the safety profile of Ondansetron, Ramosetron and Palonosetron. 150 female patients undergoing elective Laparoscopic Cholecystectomy were randomly divided into 3 groups with 50 patients each and received 4mg of Ondansetron, 0.3mg of Ramosetron and 0.075mg of Palonosetron respectively for PONV prophylaxis. Patients were observed for QTc interval changes &other side effects like headache, dizziness, drowsiness and myalagia in addition to incidence of post operative nausea & vomiting. The incidence of QTc interval prolongation at various time intervals and side effects like headache, dizziness, drowsiness, myalagia also did not show any statistically significant difference. We concluded that safety profile and side effects of all the three drugs were comparable when used in this manner. As for as QTc interval change is concerned both ondansetron & Ramosetron caused the prolongation of corrected QTc interval but in no patient it was found to be more than 470 msen_US
dc.identifier.citationAnju Jamwal, Mukta Jatindera, Renu Wakhloo, Rajdeep Kour. Safety Profile of Various 5HT3 Receptor Antagonists Used for PONV Prophylaxis. JK Science Journal of Medical Education and Research. 2016 Apr-Jun;18(2): 111-115.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179415
dc.language.isoenen_US
dc.source.urihttps://www.jkscience.org/archives/volume182/13-%20Original%20Article.pdfen_US
dc.subjectIVRAen_US
dc.subjectLignocaineen_US
dc.subjectRopivacaineen_US
dc.titleSafety Profile of Various 5HT3 Receptor Antagonists Used for PONV Prophylaxis.en_US
dc.typeArticleen_US
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