Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action.
| dc.contributor.author | Preethi, Korengath Chandran | en_US |
| dc.contributor.author | Kuttan, Girija | en_US |
| dc.contributor.author | Kuttan, Ramadasan | en_US |
| dc.date.accessioned | 2009-05-28T13:25:10Z | |
| dc.date.available | 2009-05-28T13:25:10Z | |
| dc.date.issued | 2009-02-21 | en_US |
| dc.description.abstract | Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-alpha production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis. | en_US |
| dc.description.affiliation | Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India. | en_US |
| dc.identifier.citation | Preethi KC, Kuttan G, Kuttan R. Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action. Indian Journal of Experimental Biology. 2009 Feb; 47(2): 113-20 | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/59384 | |
| dc.language.iso | eng | en_US |
| dc.source.uri | https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.asp | en_US |
| dc.source.uri | https://nopr.niscair.res.in/bitstream/123456789/3072/1/IJEB%2047%282%29%20113-120.pdf | en_US |
| dc.title | Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action. | en_US |
| dc.type | Journal Article | en_US |
| dc.type | Research Support, Non-U.S. Gov't | en_US |