Simultaneous oral 5-fluorouracil, mitomycin C and radiation therapy in the treatment of localy advanced carcinoma of uterine cervix.
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Date
1996-05
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Abstract
Locally advanced carcinoma of the uterine cervix usually has a poor prognosis with high incidence of persistent disease and local recurrence which contributes to distressing symptoms and poor survival rates. The poor prognosis in this group of patient has remained unchanged over the last decade in spite of the additional of other therapeutic measures. Between January 1993 and June 1994, 20 patients with locally advanced carcinoma of the uterine cervix were treated with oral 5-fluorouracil, oral mitomycin C, simultaneously with radiotherapy. While another group of 18 patients, during the same period, were treated by conventional radiotherapy alone. The result of this study indicate an improvement in local control using the combined therapy: 83.33% vs 66.66% in stage IIB and 78.57% vs 41.66% in stage IIIB. The toxicity and side effects of the combination therapy were minimal. The result suggest that a combination of chemotherapy together with radiotherapy can be an improved method of treatment for locally advanced carcinoma of the uterine cervix.
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Simultaneous oral 5-fluorouracil, Mitomycin C, Radiation therapy, Localy advanced carcinoma, Uterine cervix
Citation
Sangruchi Supatra. Simultaneous oral 5-fluorouracil, mitomycin C and radiation therapy in the treatment of localy advanced carcinoma of uterine cervix. Siriraj Medical Journal, 1996 May; 48(5): 425-431.