In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells.
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Date
2014-10
Journal Title
Journal ISSN
Volume Title
Publisher
NISCAIR CSIR India.
Abstract
In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 µg/ml was evaluated against eight human cancer cell lines — A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.
Description
Keywords
Mentha Spp., Cancer cells, SRB assay
Citation
Sharma Vikas, Hussain Shabir, Gupta Moni, Saxena Ajit Kumar. In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells. Indian Journal of Biochemistry & Biophysics. 2014 Oct; 51(5): 416-419.