Cost-effectiveness analysis of serological prenatal screening for pregnant women in King Abdulaziz University Hospital: a single-center retrospective study

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dc.contributor.authorAsiri, Atheer Yahya Saeeden_US
dc.contributor.authorAlsawa, Ibtisam Talak Audallahen_US
dc.contributor.authorAnas, Mahmoud Omar Fallatahen_US
dc.contributor.authorSondos, Sami Husseinen_US
dc.contributor.authorHisham ,Z. Alshehrien_US
dc.contributor.authorAseel, Ahmed Mohammedali Aljahdalien_US
dc.contributor.authorArwa, Zuhair Fatanien_US
dc.contributor.authorSamera, Albasrien_US
dc.date.accessioned2020-05-06T09:52:57Z
dc.date.available2020-05-06T09:52:57Z
dc.date.issued2020-01
dc.description.abstractBackground: Congenital primary infections with Toxoplasma gondii, cytomegalovirus (CMV), Epstein–Bar virus (EBV), rubella, and hepatitis B virus (HBV) are viral infections transmitted transplacentally through the blood to the fetus and can be life-threatening. Therefore, we aimed to determine the prevalence of these infections and assess the cost-effectiveness of blood tests among pregnant women with positive serologies.Methods: This retrospective review was conducted among pregnant women with positive prenatal screening serology test results between January 2013 to July 2018. A p-value of <0.05 was used to calculate statistical significance.Results: Overall, 9095 pregnant women delivered in the last 5 years. Of these, 97 had positive prenatal screening serology and were enrolled in our study. Of 97, 61 (62.9%) were Saudis and 36 (37.1%) non-Saudis. The prevalence rates of rubella, CMV, EBV, and HBV were 78.35%, 59.79%, 14.43%, and 5.15%, respectively. Additionally, 44 of 97 women developed undesired antepartum outcomes, whereas 47 had adverse neonatal outcomes. CMV, HBV, and rubella were significantly associated with adverse pregnancy outcomes (P<0.005). During the study period, USD 1460228.27 was spent to screen 9095 pregnant women and USD 15573.68 to diagnose 97 pregnant women with positive serology.Conclusions: Because infections with toxoplasma, CMV, EBV, rubella, and HBV can cause serious risk to the mother and fetus during pregnancy. Thus, setting new hospital policies regarding early screening for high-risk pregnancies and early detection of these infections during prenatal visits are inevitable to avoid undesired outcomes.en_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Oobstetrics and Ggynecology, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.citationAsiri Atheer Yahya Saeed, Alsawa Ibtisam Talak Audallah, Anas Mahmoud Omar Fallatah, Sondos Sami Hussein, Hisham Z. Alshehri, Aseel Ahmed Mohammedali Aljahdali, Arwa Zuhair Fatani, Samera Albasri. Cost-effectiveness analysis of serological prenatal screening for pregnant women in King Abdulaziz University Hospital: a single-center retrospective study. International Journal of Community Medicine and Public Health. 2020 Jan; 7(1): 54-60en_US
dc.identifier.issn2394-6032
dc.identifier.issn2394-6040
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202112
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2394-6040.ijcmph20195832en_US
dc.subjectPrenatal screeningen_US
dc.subjectCongenital primary infectionsen_US
dc.subjectFetal healthen_US
dc.titleCost-effectiveness analysis of serological prenatal screening for pregnant women in King Abdulaziz University Hospital: a single-center retrospective studyen_US
dc.typeJournal Articleen_US
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