Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR.

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dc.contributor.authorMannoor, M Kaiissaren_US
dc.contributor.authorVanisaveth, Viengxayen_US
dc.contributor.authorKeokhamphavanh, Boualyen_US
dc.contributor.authorToma, Hiromuen_US
dc.contributor.authorWatanabe, Hisamien_US
dc.contributor.authorKobayashi, Junen_US
dc.contributor.authorHatabu, Toshimitsuen_US
dc.contributor.authorTaguchi, Naoen_US
dc.contributor.authorHongvangthong, Bousyen_US
dc.contributor.authorPhetsouvanh, Rattanaxayen_US
dc.contributor.authorPhompida, Samlaneen_US
dc.contributor.authorKano, Shigeyukien_US
dc.contributor.authorSato, Yoshiyaen_US
dc.date.accessioned2009-05-27T14:40:04Z
dc.date.available2009-05-27T14:40:04Z
dc.date.issued2005-09-28en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria.en_US
dc.description.affiliationDivision of Tropical Parasitology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. kaiissar@med.u-ryukyu.ac.jpen_US
dc.identifier.citationMannoor MK, Vanisaveth V, Keokhamphavanh B, Toma H, Watanabe H, Kobayashi J, Hatabu T, Taguchi N, Hongvangthong B, Phetsouvanh R, Phompida S, Kano S, Sato Y. Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Sep; 36(5): 1092-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30754
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2005_36_5/03-3536.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaosen_US
dc.subject.meshMalaria, Falciparum --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPyrimethamine --administration & dosageen_US
dc.subject.meshSulfadoxine --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titlePyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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