Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR.
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Date
2005-09-28
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Abstract
A 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Mannoor MK, Vanisaveth V, Keokhamphavanh B, Toma H, Watanabe H, Kobayashi J, Hatabu T, Taguchi N, Hongvangthong B, Phetsouvanh R, Phompida S, Kano S, Sato Y. Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Sep; 36(5): 1092-5