Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.

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dc.contributor.authorMittal, Nen_US
dc.contributor.authorGupta, Nen_US
dc.contributor.authorGoyal, Nen_US
dc.contributor.authorSingh, A Ken_US
dc.contributor.authorGuru, P Yen_US
dc.contributor.authorPandey, V Cen_US
dc.contributor.authorRastogi, A Ken_US
dc.date.accessioned2009-05-28T13:47:29Z
dc.date.available2009-05-28T13:47:29Z
dc.date.issued1997-04-01en_US
dc.description.abstractDuring L. donovani infection in golden hamsters, tremendous hepatic damage was observed as apparent from increased activities of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, succinate dehydrogenase, glucose-6-phosphatase and acid ribonuclease. The levels of cytochrome P-450 and related monooxygenases, viz. aniline hydroxylase and aminopyrine-N-demethylase registered significant decrease in infected animals. Sodium stibogluconate, a standard antileishmanial drug, though caused the removal of parasites from infected tissues, but did not help in the recovery of deranged hepatic markers. The results explain the higher mortality of stibanate treated infected animals as compared to untreated animals infected with L. donovani.en_US
dc.description.affiliationDivision of Biochemistry, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationMittal N, Gupta N, Goyal N, Singh AK, Guru PY, Pandey VC, Rastogi AK. Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection. Indian Journal of Experimental Biology. 1997 Apr; 35(4): 393-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59869
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimony Sodium Gluconate --pharmacologyen_US
dc.subject.meshAntiprotozoal Agents --pharmacologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshLeishmania donovanien_US
dc.subject.meshLeishmaniasis, Visceral --drug therapyen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshMixed Function Oxygenases --metabolismen_US
dc.titleEffect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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