Desmodium gangeticum: a potent anti-ulcer agent.

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dc.contributor.authorDharmani, Poonamen_US
dc.contributor.authorMishra, Pushpesh Kumaren_US
dc.contributor.authorMaurya, Rakeshen_US
dc.contributor.authorChauhan, Vinay Singhen_US
dc.contributor.authorPalit, Gautamen_US
dc.date.accessioned2009-05-28T12:36:29Z
dc.date.available2009-05-28T12:36:29Z
dc.date.issued2005-06-05en_US
dc.description.abstractThe present study was designed to investigate anti-ulcerogenic property of ethanolic extract of Desmodium gangeticum (DG) against cold restraint (CRU, 2 hr cold restraint stress), aspirin (ASP, 150 mg/kg orally), alcohol (AL, absolute alcohol 1 ml/200gm) and pyloric ligation (PL, 4 hr pylorus ligation) induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0.25 mg/kg) induced duodenal ulcer in guinea pigs. We found that DG at a dose of 200mg/kg, (orally), markedly decreased the incidence of ulcers in all the above models. DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. Sucralfate as standard drug showed 92.64% protection in AL model. DG significantly reduced acid secretion 41.61%, whereas OMZ produced 43.13% reduction. Treatment with DG showed increase in mucin secretion by 56.17%, whereas OMZ showed 12.45% increase. Anti-ulcer effect of DG may be due to its cytoprotective effect along with antisecretory activity and could act as a potent therapeutic agent against peptic ulcer disease.en_US
dc.description.affiliationDivision of Pharmacology, Central Drug Research Institute, Lucknow 226 001, India.en_US
dc.identifier.citationDharmani P, Mishra PK, Maurya R, Chauhan VS, Palit G. Desmodium gangeticum: a potent anti-ulcer agent. Indian Journal of Experimental Biology. 2005 Jun; 43(6): 517-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58311
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAlcohols --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agents --pharmacologyen_US
dc.subject.meshAspirin --pharmacologyen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDuodenal Ulcer --drug therapyen_US
dc.subject.meshEthanol --chemistryen_US
dc.subject.meshFabaceae --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHistamine --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshOmeprazole --chemistryen_US
dc.subject.meshPeptic Ulcer --metabolismen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStomach Ulcer --drug therapyen_US
dc.subject.meshSucralfate --chemistryen_US
dc.titleDesmodium gangeticum: a potent anti-ulcer agent.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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