Ageing Induced Hyperproduction of Reactive Oxygen Species and Dysbalance in Enzymatic Link of Antioxidant Defense System of Skin and Therapeutic Efficacy of Artichoke Extract

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dc.contributor.authorSukoyan, Galina V.en_US
dc.contributor.authorGongadze, Nikoloz V.en_US
dc.contributor.authorDemina, Natalya B.en_US
dc.contributor.authorGolovach, Veronika V.en_US
dc.contributor.authorTsivtsivadze, Edisher T.en_US
dc.contributor.authorBakuridze, Alesha D.en_US
dc.date.accessioned2020-01-02T06:14:27Z
dc.date.available2020-01-02T06:14:27Z
dc.date.issued2019-04
dc.description.abstractSkin aging is multitarget persistence processing that immediately involve hyperproduction of free radicals under influence of intrinsic and extrinsic factors and deterioration in intimal antioxidant defense system. The goal of the study was the evaluation of the anti-oxidant potential of artichoke standartizated extracts, 2%, as a protective strategy against skin age-associated oxidative damage caused by D-galactose (D-gal) in rats. 58 female Wistar rats included in the experimental design. D-gal-induced aging was reproduced in 36 animals of main group, and 12 rats included in control group. All animals in main group were randomized for 3 groups: I – animals with skin aging reproduced model receive saline, II – animals with skin aging rats receive artichoke extracts (with content of chloroagenic acid 2.0%) in a dose of intradermal injection 0.13 mg/kg and main III group - animals with skin aging receive 1.3 mg/kg artichoke extract twice at weeks during 4 weeks. Influence of artichoke extracts restores skin relative weight and leads to decreasing the rate of generation of superoxide anion, hydrogen peroxide and lipid peroxidation (LPx), increasing activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and reverse ratio SOD/(catalase+GPx) to the production of H2O2 from superoxide dismutation coupling with the decrease ratio of generated O2-/H2O2. Low-dose of intradermally microinjection of artichoke extracts, 2%, activated the enzymatic link in innate antioxidant defense system in D-gal-induced skin aging model and could be recommended for applications in cosmetics as antiaging mesotherapy.en_US
dc.identifier.affiliationsInternational Center of Introduction of New Biomedical Technology (Assigned of NV Karsanov Scientific Centre of Introduction of New Biomedical Technology), Tbilisi, Georgia.en_US
dc.identifier.affiliationsDepartment of Pharmacotherapy and Pharmacology, Tbilisi State Medical University, Tbilisi, Georgia.en_US
dc.identifier.affiliationsDepartment of Pharmacy Technology of Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.en_US
dc.identifier.affiliationsInternational Center of Introduction of New Biomedical Technology (Assigned of NV Karsanov Scientific Centre of Introduction of New Biomedical Technology), Tbilisi, Georgia.en_US
dc.identifier.affiliationsInternational Center of Introduction of New Biomedical Technology (Assigned of NV Karsanov Scientific Centre of Introduction of New Biomedical Technology), Tbilisi, Georgia.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Technology, Tbilisi State Medical University, Tbilisi, Georgia.en_US
dc.identifier.citationSukoyan Galina V., Gongadze Nikoloz V., Demina Natalya B., Golovach Veronika V., Tsivtsivadze Edisher T., Bakuridze Alesha D.. Ageing Induced Hyperproduction of Reactive Oxygen Species and Dysbalance in Enzymatic Link of Antioxidant Defense System of Skin and Therapeutic Efficacy of Artichoke Extract. European Journal of Medicinal Plants. 2019 Apr; 27(4): 1-10en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189465
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume27en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2019/v27i430118en_US
dc.subjectSkinen_US
dc.subjectagingen_US
dc.subjectartichoke extracten_US
dc.subjectoxidant defense systemen_US
dc.subjectsuperoxide anionen_US
dc.subjectglutathione systemen_US
dc.titleAgeing Induced Hyperproduction of Reactive Oxygen Species and Dysbalance in Enzymatic Link of Antioxidant Defense System of Skin and Therapeutic Efficacy of Artichoke Extracten_US
dc.typeJournal Articleen_US
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