Housing under the pyramid reduces susceptibility of hippocampal CA3 pyramidal neurons to prenatal stress in the developing rat offspring.

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dc.contributor.authorMurthy, Krishna Dilip
dc.contributor.authorGeorge, Mitchel Constance
dc.contributor.authorRamasamy, Perumal
dc.contributor.authorMustapha, Zainal Arifin
dc.date.accessioned2014-04-28T10:41:36Z
dc.date.available2014-04-28T10:41:36Z
dc.date.issued2013-12
dc.description.abstractMother-offspring interaction begins before birth. The foetus is particularly vulnerable to environmental insults and stress. The body responds by releasing excess of the stress hormone cortisol, which acts on glucocorticoid receptors. Hippocampus in the brain is rich in glucocorticoid receptors and therefore susceptible to stress. The stress effects are reduced when the animals are placed under a model wooden pyramid. The present study was to first explore the effects of prenatal restraint-stress on the plasma corticosterone levels and the dendritic arborisation of CA3 pyramidal neurons in the hippocampus of the offspring. Further, to test whether the pyramid environment would alter these effects, as housing under a pyramid is known to reduce the stress effects, pregnant Sprague Dawley rats were restrained for 9 h per day from gestation day 7 until parturition in a wire-mesh restrainer. Plasma corticosterone levels were found to be significantly increased. In addition, there was a significant reduction in the apical and the basal total dendritic branching points and intersections of the CA3 hippocampal pyramidal neurons. The results thus suggest that, housing in the pyramid dramatically reduces prenatal stress effects in rats.en_US
dc.identifier.citationMurthy Krishna Dilip, George Mitchel Constance, Ramasamy Perumal, Mustapha Zainal Arifin. Housing under the pyramid reduces susceptibility of hippocampal CA3 pyramidal neurons to prenatal stress in the developing rat offspring. Indian Journal of Experimental Biology. 2013 Dec; 51(12): 1070-1078.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150294
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/24556en_US
dc.subjectCA3 pyramidal neuronsen_US
dc.subjectChronic restraint-stressen_US
dc.subjectCorticosteroneen_US
dc.subjectGestationen_US
dc.subjectHippocampusen_US
dc.subjectOffspringen_US
dc.subjectPrenatal stressen_US
dc.subjectPyramiden_US
dc.subject.meshAnimals
dc.subject.meshCA3 Region, Hippocampal --metabolism
dc.subject.meshCA3 Region, Hippocampal --physiology
dc.subject.meshCorticosterone --blood
dc.subject.meshDendrites --metabolism
dc.subject.meshDendrites --physiology
dc.subject.meshFemale
dc.subject.meshHousing
dc.subject.meshHydrocortisone --blood
dc.subject.meshMaternal-Fetal Relations --physiology
dc.subject.meshNeurons --metabolism
dc.subject.meshNeurons --physiology
dc.subject.meshPregnancy
dc.subject.meshPyramidal Cells --metabolism
dc.subject.meshRats
dc.subject.meshStress, Psychological
dc.titleHousing under the pyramid reduces susceptibility of hippocampal CA3 pyramidal neurons to prenatal stress in the developing rat offspring.en_US
dc.typeArticleen_US
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