Evaluation of Reaction Pattern of Skin Diseases in Oman: A Study Base on Immunoflurescence and Light Microscopy Investigation Onlhy.
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Date
2014-11-01
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Abstract
Aims: The aim of this study was to evaluate various reaction pattern of skin diseases in
Oman using immunofluorescence and light microscopy investigation only.
Methodology: A total of 187 skin biopsies were retrospectively analyzed at Sultan
Qaboos University Hospital between 2006 and 2010. The presence of immune-reactants
(IgA, IgG, IgM, C3 and Fibrin) and the final diagnosis by heamatoxylin and eosin stain in
skin biopsy were investigated.
Results: Females (59.36%) predominated over males (40.64%). Adults, aged between
26 and 44years, had the highest cases of skin diseases. The most frequent diagnosis
were vesiculo bullous (n=71), lichenoid (n=69), vasculopathic (n=19) and epidermal
disease (n=13) groups. Vesiculo bullous group showed different deposits of IgA, IgG,
IgM, C3 and Fibrin with 19.72%, 23.94%, 8.54%, 21.13%, 11.27%, respectively.
Psoriasis (n=2) and reactive condition (n=1) groups were the lowest pattern of skin
diseases. IgG was positive in one case of psoriasis and there is a total absence of
positive immune-reactants in epidermal disease and reactive condition groups.Conclusion: Based on the findings of this study, this retrospective study showed that
vesiculo bullous group followed by lichenoid group were the most common skin disease
groups detected by immunofluorescence in Oman, while psoriasis and reactive condition
groups were the least frequent. Although all immune-reactants were low in their
positivity, they were an important component in the final diagnosis of skin biopsies.
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Keywords
Immunofluorescence, lichenoid, psoriasis, skin disease, vesiculo bullous
Citation
Alwahaibi Nasar Yousuf, Alabri Ghena Khafan, Alsinawi Shadia Said, Qureshi Asim. Evaluation of Reaction Pattern of Skin Diseases in Oman: A Study Base on Immunoflurescence and Light Microscopy Investigation Onlhy. British Journal of Medicine and Medical Research. 2014 Nov; 4(31): 5033-5042.