Acute toxicity evaluation of homeopathic preparation of Gymnema sylvestre and analysis of its chemical constituents

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dc.contributor.authorShukla, Avanishen_US
dc.contributor.authorMuhammed, Imtiaz Khaliden_US
dc.contributor.authorSheshala, Ravien_US
dc.contributor.authorMhaisker, Ibrahim Usmanen_US
dc.contributor.authorRampal, Krishnaen_US
dc.date.accessioned2020-10-16T08:50:37Z
dc.date.available2020-10-16T08:50:37Z
dc.date.issued2020-07
dc.description.abstractIn many countries, homeopathic preparation is believed to be an effective medicine for various ailments.However, there are limited scientific evidences in regard to its usage, safety, and efficacy. It is necessary toupdate this age-old scientific wisdom in different aspects, including pharmacologic and therapeutic potentials.In this study, we assessed the safety profile of homeopathic preparation of Gymnema sylvestre (HPGS). Itschemical constituents were deciphered using LCMS approaches. HPGS was subjected to an acute toxicitystudy (OECD-423 guidelines) using Sprague Dawley rats. The administration of HPGS did not produce anytoxic symptoms or show mortality at the dose level of 300 mg/kg body weight. Phytochemical analysis revealedthat HPGS contained alkaloids, saponins, and flavonoids. These results demonstrated the non-toxic nature ofHPGS in vivo, suggesting a long-term usage in clinical practices when administered orallyen_US
dc.identifier.affiliationsFaculty of Traditional and Complementary Medicine, Cyberjaya University College of Medical Science, Cyberjaya, Malaysiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cyberjaya University College of Medical Science, Cyberjaya, Malaysiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, University Teknologi MARA UiTM, Puncak Alam, Malaysiaen_US
dc.identifier.affiliationsFaculty of Traditional and Complementary Medicine, Cyberjaya University College of Medical Science, Cyberjaya, Malaysiaen_US
dc.identifier.affiliationsCentre for Graduate Studies, Research and Commercialization, Cyberjaya University College of Medical Science, Cyberjaya, Malaysiaen_US
dc.identifier.citationShukla Avanish, Muhammed Imtiaz Khalid, Sheshala Ravi, Mhaisker Ibrahim Usman, Rampal Krishna. Acute toxicity evaluation of homeopathic preparation of Gymnema sylvestre and analysis of its chemical constituents. Journal of Applied Biology & Biotechnology. 2020 Jul; 2020 Jul: 33-37en_US
dc.identifier.issn2455-7005
dc.identifier.issn2347-212X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209917
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber4en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org//10.7324/JABB.2020.80405en_US
dc.subjectGymnema sylvestreen_US
dc.subjecthomeopathyen_US
dc.subjecttoxicityen_US
dc.subjectLC/MSen_US
dc.subjectSprague Dawley ratsen_US
dc.titleAcute toxicity evaluation of homeopathic preparation of Gymnema sylvestre and analysis of its chemical constituentsen_US
dc.typeJournal Articleen_US
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