Unveiling the Impact of Allethrin-Related Mosquito Coil Exposure on Testicular Histology: Investigating the Protective Role of Vitamin C and withdrawal dynamics

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dc.contributor.authorSingh, Heenaen_US
dc.contributor.authorSingh, Raghvendraen_US
dc.contributor.authorDiwan, R.K.en_US
dc.contributor.authorRani, Archanaen_US
dc.contributor.authorManik, Punitaen_US
dc.contributor.authorKumar, Navneeten_US
dc.date.accessioned2025-05-09T07:25:07Z
dc.date.available2025-05-09T07:25:07Z
dc.date.issued2024-12
dc.description.abstractIntroduction: Allethrin is a common pyrethroid, one of the major component of mosquito coils that is noxious. The aim of the current study is to see the protective effect of Vitamin C on an induced testicular damage by Allethrin as well as comparing it to withdrawal prognosis. Material and method: The Wistar rats comprised of following groups: Group 1-control group , Groups II, III, and IV- exposure groups. Each group consisted of 12 rats. These were subjected to mosquito coil fumes continuously overnight for eight hours every day for a duration of twelve weeks. To demonstrate the effects of withdrawal, Wistar rats from group III were kept in an environment free from additional exposure for eight weeks after the 12-week exposure period. In addition, Group IV received Vitamin C. Result: Group II exhibited significant alterations in the testicular architecture, including conspicuous shrinkage of seminiferous tubules, an increase in intertubular space, thickening and disruption of the basement membrane, decreased thickness of the germinal epithelium, sloughing of germinal cells into the lumen, reduced numbers and size of spermatogenic cells, retracted cytoplasmic processes of Sertoli cells, interstitial edema, lipid vacuolation, and deformation of Leydig cells. Withdrawal in group III showed some histopathological improvements, while group IV, treated with Vitamin C, demonstrated even more remarkable enhancements. Conclusion: Exposure of Wistar Albino rats to mosquito coils containing allethrin led to notable histopathological changes. However, these adverse effects can be ameliorated by incorporating daily antioxidant intake, such as Vitamin C supplementation.en_US
dc.identifier.affiliationsAssistant Professor, Anatomy, King George’s Medical university, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor, Anatomy, King George’s Medical university, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor, Anatomy, King George’s Medical university, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor, Anatomy, King George’s Medical university, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor, Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh Heena, Singh Raghvendra, Diwan R.K., Rani Archana, Manik Punita, Kumar Navneet . Unveiling the Impact of Allethrin-Related Mosquito Coil Exposure on Testicular Histology: Investigating the Protective Role of Vitamin C and withdrawal dynamics . International Journal of Anatomy and Research. 2024 Dec; 12(4): 9057-9064en_US
dc.identifier.issn2321-4287
dc.identifier.issn2321-8967
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/243194
dc.languageenen_US
dc.publisherIMED Research Publicationsen_US
dc.relation.issuenumber4en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.16965/ijar.2024.210en_US
dc.subjectMosquito Coilen_US
dc.subjectAllethrinen_US
dc.subjectTesticularen_US
dc.subjectSeminiferous Tubulesen_US
dc.subjectVitamin Cen_US
dc.subjectAntioxidanten_US
dc.titleUnveiling the Impact of Allethrin-Related Mosquito Coil Exposure on Testicular Histology: Investigating the Protective Role of Vitamin C and withdrawal dynamicsen_US
dc.typeJournal Articleen_US
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