Histopathological Spectrum and Immunohistochemistry Expression of Pediatric Solid Malignant Tumors: An Observational Study

Simple item page
dc.contributor.authorPatel, Bhumikaen_US
dc.contributor.authorKunda, Jagadaleen_US
dc.contributor.authorBharadwaj, Reenaen_US
dc.date.accessioned2025-08-13T09:33:16Z
dc.date.available2025-08-13T09:33:16Z
dc.date.issued2025-03
dc.description.abstractIntroduction: The major leading cause of disease-related mortality in children is childhood cancer. It can be difficult to make an accurate diagnosis using only histopathology due to overlapping features and similar histomorphological appearances in various cancers. Immunohistochemistry (IHC) markers can help distinguish tumors that show similar histomorphological features.Aims & Objectives: This study was undertaken to evaluate the histopathological spectrum of pediatric solid malignant neoplasms with IHC and to assess the role of IHC in pediatric solid malignant tumors.Study Design: An observational study of resected malignant solid tumors in the pediatric population including Gross and Histopathological examination was conducted.Materials and methods: 55 samples were collected for five years. All samples were processed for routine histopathology and IHC was done on the majority of these samples. Results: The top five categories of tumors were retinoblastomas, lymphomas, neuroblastomas, bone and soft tissue tumors, and renal and reproductive system tumors. The mean age is 6.6 years and most commonly presented in 0-5 years of age constituting 30 cases. 35 cases seen were in male patients, and 20 in female patients. IHC was performed on 44 cases for confirmation of diagnosis. For the rest of the 11 cases, the histopathological study is the gold standard for diagnosis. Conclusion: An integrated approach including Histomorphological features is required for provisional diagnosis and IHC is necessary for final diagnosis and further characterization.en_US
dc.identifier.affiliationsDepartment of Pathology, Bharati Vidyapeeth, Deemed to be University Medical College, Pune, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Bharati Vidyapeeth, Deemed to be University Medical College, Pune, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Bharati Vidyapeeth, Deemed to be University Medical College, Pune, Indiaen_US
dc.identifier.citationPatel Bhumika, Kunda Jagadale, Bharadwaj Reena . Histopathological Spectrum and Immunohistochemistry Expression of Pediatric Solid Malignant Tumors: An Observational Study . JK Science Journal of Medical Education and Research. 2025 Mar; 27(1): 26-31en_US
dc.identifier.issn0972-1177
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252419
dc.languageenen_US
dc.publisherDr. Annil Mahajan from Jammu (J&K), Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume27en_US
dc.source.urihttps://journals.indexcopernicus.com/api/file/viewByFileId/2343079en_US
dc.subjectPediatricen_US
dc.subjectSolid Tumoursen_US
dc.subjectMalignancyen_US
dc.subjectImmunohistochemistryen_US
dc.titleHistopathological Spectrum and Immunohistochemistry Expression of Pediatric Solid Malignant Tumors: An Observational Studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
jksjmer2025v27n1p26.pdf
Size:
959.56 KB
Format:
Adobe Portable Document Format
Download
Collections
JK Science Journal of Medical Education and Research