Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats.

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dc.contributor.authorSubramoniam, Aen_US
dc.contributor.authorEvans, D Aen_US
dc.contributor.authorRajasekharan, Sen_US
dc.contributor.authorPushpangadan, Pen_US
dc.date.accessioned2009-05-28T16:31:22Z
dc.date.available2009-05-28T16:31:22Z
dc.date.issued1998-04-26en_US
dc.description.abstractTrichopus zeylanicus extract has been evaluated for its antihepatotoxic and choleretic activities in rats. The plant leaf suspension (1000 mg/kg; wet weight) as well as its methanol extract (100 mg/kg) showed a remarkable hepatoprotective activity against paracetamol-induced hepatotoxicity as judged from the serum marker enzymes, liver histology and levels of lipid peroxides in liver. The effect of the methanol extract was found to be concentration dependent. The water and hexane extracts were almost inactive. The methanol extract (100 mg/kg) also exhibited choleretic activity in anesthetized normal rats. In short, we report here for the first time the antihepatotoxic as well as choleretic properties of T. zeylanicus.en_US
dc.description.affiliationEthnopharmacology and Ethnomedicine Divisions, Tropical Botanic Garden and Research Institute, Thiruvananthapuram, India.en_US
dc.identifier.citationSubramoniam A, Evans DA, Rajasekharan S, Pushpangadan P. Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats. Indian Journal of Experimental Biology. 1998 Apr; 36(4): 385-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63338
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetaminophen --poisoningen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHepatitis, Toxic --prevention & controlen_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleHepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats.en_US
dc.typeJournal Articleen_US
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