Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation.

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dc.contributor.authorRasool, Bazigha K Abdul
dc.contributor.authorAzeez, Oday S
dc.contributor.authorLootah, Hamda A
dc.contributor.authorAbusharbain, Iman M
dc.contributor.authorAbu-Alhaj, Hiba A
dc.contributor.authorNessa, Fazilatun
dc.date.accessioned2015-09-17T11:35:55Z
dc.date.available2015-09-17T11:35:55Z
dc.date.issued2014-11
dc.description.abstractThis study aimed at the investigation of piroxicam-niosomal hydrogel for ocular targeting to prolong and enhance its local analgesic activity. Various formulations were prepared, characterized and evaluated ex vivo for their transocular permeation using excised cow cornea. The prepared niosomes had distinct spherical multi-lamellar shape and mean vesicle size between 1.25±0.81μm and 7.47±0.85μm. Relevant increase in drug EE% was obtained with increase of cholesterol content and surfactant’s hydrophobicity. Drug retention in vesicles was significantly (p<0.05) higher at refrigerated condition than that at the room temperature. Prolonged drug release was achieved with high niosomal cholesterol content and the mechanism of drug release can be described as Fickian diffusion. The niosomal hydrogel showed 3.7 Permeability Improvement Ratio comparing to piroxicam aqueous suspension. The optimized niosomal gel showed prolonged drug release and enhanced piroxicam ocular bioavailability due to the formation of an amorphous drug form within the gel.en_US
dc.identifier.citationRasool Bazigha K Abdul, Azeez Oday S, Lootah Hamda A, Abusharbain Iman M, Abu-Alhaj Hiba A, Nessa Fazilatun. Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation. British Journal of Pharmaceutical Research. 2014 Nov; 4(21): 2494-2510.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163568
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/6686en_US
dc.subjectPiroxicamen_US
dc.subjectniosomesen_US
dc.subjectspan surfactantsen_US
dc.subjecthydrogelen_US
dc.subjectocularen_US
dc.subjectbioavailabilityen_US
dc.subjectextended releaseen_US
dc.titleExtended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation.en_US
dc.typeArticleen_US
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