Comparison of safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough: a randomized open label phase IV clinical trial

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dc.contributor.authorGhosh, Arijiten_US
dc.date.accessioned2020-04-23T07:58:25Z
dc.date.available2020-04-23T07:58:25Z
dc.date.issued2019-10
dc.description.abstractBackground: To compare safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough.Methods: Patients fulfilling the selection criteria were randomized into two groups. Patients in group A were administered dextromethorphan cough lozenges (5 mg) thrice daily for 7 days. Patients in group B were administered syrup levocloperastine (20 mg/5 ml) 5 ml thrice daily for 7 days. Severity and frequency of cough, and Leicester Cough Questionnaire (LCQ) score were assessed at the end of day 7.Results: Levocloperastine significantly decreased (p<0.5) severity and frequency of cough compared to dextromethorphan at day 7. Levocloperastine also significantly increased LCQ score compared to dextromethorphan at day 7.Conclusions: Levocloperastine is significantly more effective compared to dextromethorphan in treatment of dry cough.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Malda Medical College, Malda, West Bengal, Indiaen_US
dc.identifier.citationGhosh Arijit. Comparison of safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough: a randomized open label phase IV clinical trial. International Journal of Basic & Clinical Pharmacology. 2019 Oct; 8(10): 2284-2287en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200374
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20194272en_US
dc.subjectLevocloperastineen_US
dc.subjectDry coughen_US
dc.subjectDextromethorphanen_US
dc.titleComparison of safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough: a randomized open label phase IV clinical trialen_US
dc.typeJournal Articleen_US
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