Diabetic Ketoacidosis in Two Nigerian Adolescents with Homozygous Sickle Cell Anaemia.
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Date
2014-08-01
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Abstract
In the tropics where the prevalence of sickle cell anaemia (SCA) is high, reports of
concurrence of sickle cell anaemia and diabetes mellitus are rare with diabetic
ketoacidosis (DKA), being rarer. In this case report, we present the cases of two Nigerian
adolescents (one male and one female) with homozygous SCA who presented in DKA.
Sickle cell anaemia was diagnosed eight and nine months respectively prior to their
presentation with DKA. There was no history of previous multiple blood transfusions.
Neither of the two cases had positive family history of diabetes mellitus. The diagnosis of
DKA in each case was based on the presence of hyperglycaemia, ketonuria and
acidosis. The families of these two patients were of low socio-economic status.
Conclusion: Although concurrent homozygous sickle cell anaemia and diabetic
ketoacidosis is rare, it does occur in Nigerian children and adolescents.
Description
Keywords
Adolescents, diabetic ketoacidosis, haemoglobinopathy, Nigeria, sickle cell anaemia
Citation
Onyiriuka Alphonsus N, Odunvbun Magdalene E, Enato lzehiuwa G. Diabetic Ketoacidosis in Two Nigerian Adolescents with Homozygous Sickle Cell Anaemia. British Journal of Medicine and Medical Research. 2014 Aug; 4(22): 4004-4010.