Effect of acute or subchronic stress on T cell response in peripheral blood: Regulatory role of vitamin D

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dc.contributor.authorDogan, Muraten_US
dc.contributor.authorSevgili, Ayse Meltemen_US
dc.contributor.authorKozanoglu, ?lknuren_US
dc.contributor.authorPehlivanoglu, Bilgeen_US
dc.date.accessioned2023-08-09T06:21:16Z
dc.date.available2023-08-09T06:21:16Z
dc.date.issued2023-01
dc.description.abstractThe immune response, orchestrated by helper (Th1, Th2, and Th17) and regulatory (Treg) T cells, is modulated by stress and Vitamin D (Vit-D). Although the immunomodulatory functions of both are known, their specific roles on Th cells have not been fully clarified, yet. On this background, we aimed to investigate the effect of acute or subchronic stress on the distribution of peripheral T lymphocytes, as well as the immunomodulatory role of Vit-D. Young adult male, Swiss-albino mice (30–40g) were allocated to the control, acute stress (AS), subchronic stress (ChS), control+Vit-D, AS+Vit-D, and ChS+Vit-D groups (n=11/group). The combined cold (2-h at 4°C)-immobilization (2-h in a restrainer) stress protocol was employed as one day in AS groups and five consecutive days in ChS groups. Vit-D (2?g/kg ip) was applied every other day, until the end of the protocol. Serum cortisol, Vit-D and cytokine levels (IL-4, IFN-?, and IL-17A) were measured, and lymphocytes from blood samples were subtyped by flow-cytometry. Stress exposure caused differential Th and Treg responses, acute stress shifting the response to Th1, and subchronic stress shifting the response to Th2. Th17 and Treg cells were lower in subchronic stress exposed mice. These changes became comparable to control values in Vit-D treated groups. The T cell response, crucial for immune system function, differs on the basis of stress exposure as such the Vit-D treatment. The tolerogenic profile created by Vit-D should be considered for management of stress-related diseases. Our results may help to provide a better understanding of disease pathogenesis.en_US
dc.identifier.affiliationsDepartment of Physiology, Faculty of Medicine, Hacettepe University, Ankara, Turkeyen_US
dc.identifier.affiliationsDepartment of Surgery, Transplant Research Institute, University of Tennessee Health Science Center, Memphis, TN, USAen_US
dc.identifier.affiliationsDepartment of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkeyen_US
dc.identifier.affiliationsDepartment of Physiology, Faculty of Medicine, Baskent University, Adana Adult Bone Marrow Transplantation Center, Yuregir, Adana, Turkeyen_US
dc.identifier.citationDogan Murat, Sevgili Ayse Meltem, Kozanoglu ?lknur, Pehlivanoglu Bilge. Effect of acute or subchronic stress on T cell response in peripheral blood: Regulatory role of vitamin D. Indian Journal of Experimental Biology. 2023 Jan; 61(1): 14-24en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222582
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber1en_US
dc.relation.volume61en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v61i01.60922en_US
dc.subjectCold-immobilization stressen_US
dc.subjectInterferon (IFN-?)en_US
dc.subjectInterleukinsen_US
dc.subjectT helper cellsen_US
dc.subjectT regulatory cellsen_US
dc.titleEffect of acute or subchronic stress on T cell response in peripheral blood: Regulatory role of vitamin Den_US
dc.typeJournal Articleen_US
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