Antioxidant and antiplasmodial activities of curcuma longa and aegle marmelos on malaria infeced mice (in vitro and in vivo).

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dc.contributor.authorKettawan, Aikkarach
dc.contributor.authorWongsansri, Kanokkarn
dc.contributor.authorChompoopong, Supin
dc.contributor.authorRungruang, Thanaporn
dc.date.accessioned2012-05-23T08:51:18Z
dc.date.available2012-05-23T08:51:18Z
dc.date.issued2012-01
dc.description.abstractThe purpose of this study is to evaluate the antioxidant activity of Thai Curcuma longa and Aegle marmelos, and their parasite suppressive effects on malaria infection in mouse model. The polyphenol content and antioxidant activities (Oxygen radical absorbance capacity (ORAC) and Ferric Reducing Antioxidant Power (FRAP)) were measured in crude extracts of Curcuma longa and Aegle marmelos. Seven-week old female ICR mice were divided into 5 groups randomly. First two groups served as control and placebo, the other 3 served as experimental groups with various concentrations; 20, 40 and 60 mg/kg, respectively. On day 0, 106 Plasmodium yoelii 17X (lethal) strain were inoculated to all mice. At day 1, placebo mice were given 30% ethanol. The latter 3 groups were treated with each concentration of each herb. Parasitemia was checked daily by tail snip bleed staining with Giemsa staining. Suppressive effects on day 4 were calculated. Student t-test was performed to display the difference among groups. Significantly different was justified at p <0.05. The antioxidant activities (both ORAC and FRAP) and polyphenol content of A. marmelos were higher than those of C. longa significantly. The suppressive effect on parasite in infected mice, there showed no effect of C. longa treatment, oppositely, at the doses of 20 and 40 mg/ kg body weigh of A. marmelos showed suppressive effect on infection by the parasite. In conclusion, a Thai traditional fruit, A. marmelos exhibited high antioxidant and antiplasmodial activities, this might be one of the candidates of the traditional plants for curing malaria.en_US
dc.identifier.citationKettawan Aikkarach, Wongsansri Kanokkarn, Chompoopong Supin, Rungruang Thanaporn. Antioxidant and antiplasmodial activities of curcuma longa and aegle marmelos on malaria infeced mice (in vitro and in vivo). Siriraj Medical Journal, 2012 Jan; 64(suppl): 78-81.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138590
dc.language.isoenen_US
dc.source.urihttps://www.sirirajmedj.com/content_download.php?content_id=2652en_US
dc.subjectPlasmodium yoeliien_US
dc.subjectMalariaen_US
dc.subjectCurcuma longaen_US
dc.subjectAegle marmelosen_US
dc.titleAntioxidant and antiplasmodial activities of curcuma longa and aegle marmelos on malaria infeced mice (in vitro and in vivo).en_US
dc.typeArticleen_US
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