Effect of melatonin in amelioration of piroxicam induced liver and renal oxidative stress in rats

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dc.contributor.authorVivek, HSen_US
dc.contributor.authorRajendra, SVen_US
dc.contributor.authorHarshitha, Nen_US
dc.contributor.authorJyothi, Yen_US
dc.contributor.authorJothi, Aen_US
dc.date.accessioned2025-06-18T11:23:09Z
dc.date.available2025-06-18T11:23:09Z
dc.date.issued2025-06
dc.description.abstractBackground: Piroxicam, a nonsteroidal anti-inflammatory drug, induces oxidative stress affecting liver and kidney function. Melatonin, a potent antioxidant, may mitigate this damage through its free radical-scavenging and tissue-protective properties. Methods: The piroxicam-induced oxidative stress model was used to evaluate the amelioration effect of melatonin at two doses (10 mg/kg and 25 mg/kg BW). The changes in the physical, physiological and biochemical characteristics in the serum, liver and renal tissue oxidative stress markers, the histopathological changes and insilico docking of melatonin with various oxidative stress marker were also studied. Results: The blood serum and tissue stress markers in the rats receiving piroxicam was considerably higher than those in the normal control (p<0.05). Pre-treatment with melatonin at doses of 10 mg/kg and 25 mg/kg resulted in a substantial amelioration in tissue oxidative stress as compared to the control group. Other than lipid peroxidation, which exhibited a significant (p<0.05) plunge when compared to the piroxicam treated group, the serum liver and renal comprehensive metabolic panel profile was significantly reduced. In the pre-treatment group, the level of total protein contents likewise increased. Further it is confirmed from the histological studies that the pre-treatment of melatonin group's liver and kidney show less tissue damage than the piroxicam-induced group, and the histo-architectural of hepato-renal cells gradually recovered and in silico docking study of melatonin with oxidative stress maker shown potential interaction with high binding energy. Conclusions: It can be concluded that pretreatment of melatonin is effective against piroxicam- induced liver and renal oxidative stress in the Wister rats.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Mallige College of Pharmacy, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacist, Krupanidhi College of Pharmacy, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsCliniEra, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationVivek HS, Rajendra SV, Harshitha N, Jyothi Y, Jothi A. Effect of melatonin in amelioration of piroxicam induced liver and renal oxidative stress in rats. International Journal of Basic & Clinical Pharmacology. 2025 Jun; 14(3): 375-381en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/248639
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20251063en_US
dc.subjectOxidative stressen_US
dc.subjectPiroxicam-induceden_US
dc.subjectTissue markersen_US
dc.subjectMelatoninen_US
dc.subjectMetabolic panel levelsen_US
dc.subjectDockingen_US
dc.titleEffect of melatonin in amelioration of piroxicam induced liver and renal oxidative stress in ratsen_US
dc.typeJournal Articleen_US
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