Mefenamic acid and diclofenac in the treatment of menorrhagia and dysmenorrhea in dysfunctional uterine bleeding: a randomized comparative study

Simple item page
dc.contributor.authorKumar, Sahilen_US
dc.contributor.authorTekur, Umaen_US
dc.contributor.authorSingh, Bhupinderen_US
dc.contributor.authorKumar, Devenderen_US
dc.date.accessioned2020-04-23T07:52:06Z
dc.date.available2020-04-23T07:52:06Z
dc.date.issued2018-10
dc.description.abstractBackground: There is a perception that Mefenamic Acid should be the preferred NSAID for menorrhagia. However, there are insufficient evidences to prove this. Further RCTs are required to compare individual NSAIDs.Purposes of the study were to assess and compare the efficacy of mefenamic acid and diclofenac in control of menorrhagia in patients with DUB, to assess and compare their analgesic effects in dysmenorrhea associated with DUB and to study their adverse effects.Methods: Sixty-eight patients were randomized into either Mefenamic Acid (n=34) or Diclofenac (n=34) group. Efficacy variables (Pictorial Blood loss Assessment Chart quantification, Number of pads used, Number of days of menstrual bleeding, Visual Analog Scale score) and adverse effects were recorded over three menstrual cycles.Results: The median reduction of menorrhagia with Mefenamic Acid was 43.39% (Range: 2.86% to 94.4%) and for Diclofenac was 57.5% (Range: 9.9% to 93.58%). The Diclofenac group showed a statistically significant decrease in median bleeding volume, median number of pads used and median number of days of bleeding compared to the Mefenamic Acid group (p<0.05, CI = 95%) but did not show a statistically significant decrease in median VAS score compared to the Mefenamic Acid group. Adverse effects with both groups were mild.Conclusions: Mefenamic Acid and Diclofenac individually managed to significantly reduce excessive bleeding compared to baseline. Diclofenac fared better than Mefenamic Acid in terms of control of excessive menstrual bleeding. Both these agents were able to reduce the menstrual pain and on comparison, were found to be equi-efficacious.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Maulana Azad Medical College, (MAMC), Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics & Gynecology, Lok Nayak Hospital, Delhi, Indiaen_US
dc.identifier.citationKumar Sahil, Tekur Uma, Singh Bhupinder, Kumar Devender. Mefenamic acid and diclofenac in the treatment of menorrhagia and dysmenorrhea in dysfunctional uterine bleeding: a randomized comparative study. International Journal of Basic & Clinical Pharmacology. 2018 Oct; 7(10): 1905-1911en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199854
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20183921en_US
dc.subjectAbnormal uterine bleedingen_US
dc.subjectDiclofenacen_US
dc.subjectDysmenorrheaen_US
dc.subjectMefenamic aciden_US
dc.subjectMenorrhagiaen_US
dc.subjectNSAIDsen_US
dc.titleMefenamic acid and diclofenac in the treatment of menorrhagia and dysmenorrhea in dysfunctional uterine bleeding: a randomized comparative studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2018v7n10p1905.pdf
Size:
250.4 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology