Characterization and localization of estrogen and progesterone receptors of human fallopian tube.

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dc.contributor.authorShah, Aen_US
dc.contributor.authorNandedkar, T Den_US
dc.contributor.authorRaghavan, V Pen_US
dc.contributor.authorParulekar, S Ven_US
dc.contributor.authorNatraj, Uen_US
dc.date.accessioned2009-05-28T12:38:23Z
dc.date.available2009-05-28T12:38:23Z
dc.date.issued1999-09-25en_US
dc.description.abstractThe cellular distribution of estrogen and progesterone receptors (ER and PR) in the human fallopian tube was investigated by immunohistochemical localization with specific monoclonal antibodies. Nuclear immunostaining was observed. Intense PR immunostaining was seen in tissues obtained at mid cycle and luteal stages of the normal menstrual cycle. On the other hand, enhanced staining for ER was seen in early follicular phase and mid cycle. Menopausal tissues showed negligible staining for both ER and PR. The ER and PR were characterized for their molecular size, anatomical distribution and levels during the menstrual cycle and in menopause. ER protein was present throughout the cycle and also during menopause. Western blot analysis revealed two forms of ER approximately 66 kDa and a truncated from approximately 49 kDa in hFT. Presence of A [approximately 90 kDa] and B [approximately 120 kDa] isoforms of human PR was detected. Follicular and early luteal tissue possessed relatively high concentration of immunoreactive PR whereas it was almost undetectable in menopausal tissues. These results suggests that ER and PR are regulated by the changing ovarian steroid hormones.en_US
dc.description.affiliationInstitute for Research in Reproduction, Mumbai, India.en_US
dc.identifier.citationShah A, Nandedkar TD, Raghavan VP, Parulekar SV, Natraj U. Characterization and localization of estrogen and progesterone receptors of human fallopian tube. Indian Journal of Experimental Biology. 1999 Sep; 37(9): 893-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58354
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshFallopian Tubes --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshReceptors, Estrogen --metabolismen_US
dc.subject.meshReceptors, Progesterone --metabolismen_US
dc.titleCharacterization and localization of estrogen and progesterone receptors of human fallopian tube.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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