Evaluation of antidiabetic efficacy of Murraya koenigii on Streptozotocin induced diabetes in experimental rats

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dc.contributor.authorSuman, Rajesh Kumaren_US
dc.contributor.authorMohanty, Ipseeta Rayen_US
dc.contributor.authorBorde, Manjusha K.en_US
dc.contributor.authorDeshmukh, Y. A.en_US
dc.contributor.authorPathak, Anuragen_US
dc.contributor.authorAdhikari, Arun Kumaren_US
dc.contributor.authorSingh, H. K.en_US
dc.date.accessioned2020-04-23T07:57:37Z
dc.date.available2020-04-23T07:57:37Z
dc.date.issued2019-08
dc.description.abstractBackground: The medicinal plant Murraya koenigii shown to have a wide variety of pharmacological activities (hypoglycemic and hypolipidemic). Objective of this study is the present study was designed to evaluate Antidiabetic and Hypolipidemic property of Murraya koenigii in experimentally induced diabetes in rats.Methods: Experimental diabetes was produced with single dose of Streptozotocin (STZ): 45 mg/kg IP. The rats were randomly allocated in various groups for 37 days. After the confirmation of diabetes on 7th day (>200 mg/dl), hydroalcoholic extract of Murraya koenigii (500 mg/kg) was administered orally to experimental rats from day 7th day and continued for 37 days thereafter. Various antidiabetic (Glucose, HbA1C), metabolic (Lipid profile), safety (pancreatic lipase, Creatinine, SGPT, Histopathology of Liver and Kidney) were evaluated in various group.Results: Efficacy of Murraya koenigii was observed on various parameter of diabetes. Administration of STZ resulted in a significant decrease in diabetic changes (increase in blood glucose, HbA1C), altered lipid profile (p<0.01) in the Control group rats as compared to sham group. Murraya koenigii treatment demonstrated significant antidiabetic indicated by restoration of blood glucose, HbA1C level (p<0.01) compared to Control group. In addition, Murraya koenigii also documented hypolipidemic property of test drug. As per biochemical assessment of Pancreatic lipase, Serum creatinine, SGPT and Histopathological report, the test drug reduce the pancreatic, liver and renal marker and also showed safe to pancreas, Liver and kidney. The histopathological assessment of the liver and kidney confirmed the biochemical findings.Conclusions: The study concluded that the Murraya koenigii possess antidiabetic efficacy.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Hind Institute of Medical Sciences, Mau, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, MGM Medical College, Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Sinhgad Dental College, Pune, Maharashtra, Indiaen_US
dc.identifier.citationSuman Rajesh Kumar, Mohanty Ipseeta Ray, Borde Manjusha K., Deshmukh Y. A., Pathak Anurag, Adhikari Arun Kumar, Singh H. K.. Evaluation of antidiabetic efficacy of Murraya koenigii on Streptozotocin induced diabetes in experimental rats. International Journal of Basic & Clinical Pharmacology. 2019 Aug; 8(8): 1906-1910en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200306
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20193200en_US
dc.subjectBlood glucoseen_US
dc.subjectDiabetesen_US
dc.subjectExperimental ratsen_US
dc.subjectMedicinal planten_US
dc.subjectMurraya koenigiien_US
dc.subjectStreptozotocinen_US
dc.titleEvaluation of antidiabetic efficacy of Murraya koenigii on Streptozotocin induced diabetes in experimental ratsen_US
dc.typeJournal Articleen_US
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