Bacteriological profile and multidrug resistance patterns of blood culture isolates in a teaching hospital in South India.

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dc.contributor.authorPavani, Gandham
dc.contributor.authorKommula, Vani Madhavi
dc.contributor.authorMudaliar, Jyothi lakshmi G
dc.date.accessioned2014-06-19T07:12:49Z
dc.date.available2014-06-19T07:12:49Z
dc.date.issued2012-07
dc.description.abstractBackground: Blood stream infections can lead to life threatening sepsis and require rapid antimicrobial treatment . The organisms implicated in these infections vary with the geographical alteration . Further , infections caused by MDR organisms are more likely to increase the risk of death in these patients . Objectives : To study the profile of organisms causing blood stream infections and analyse their antibiotic resistance patterns in our teaching hospital.: Materials and methods : Prospective study of 524 blood samples from clinically suspected cases of bacteraemia was performed over a period of three years. The isolates were identified by standard biochemical tests and antimicrobial resistance patterns were determined by CLSI guidelines. Results : Positive blood cultures were obtained in 22.9% of cases. Among the culture positives , gram positive bacteria accounted for 61.5% of cases ; the most common isolate being Staphylococcus aureus(29.2 %) . Of the gram negative isolates , bacteria belonging to Enterobacteriaceae were the predominant isolate , Klebsiella being the commonest isolate.The most sensitive drugs for gram positive isolates were Amikacin, Erythromycin , Ofloxacin and Piperacillin –Tazobactam.And the most sensitive drugs for gram negative isolates were Amoxyclav and Piperacillin – Tazobactam.The prevalence of MRSA in our Staphylococcal isolates was 37.1% and Vancomycin resistance in these isolates was 25.7%. Vancomycin resistance in E nterococcal isolates was 33.3 % .ESBL prevalence was 32.6 %.Conclusion : Increasing incidence of Drug resistant organisms in blood stream infections calls for increased efforts by clinicians to exercise caution in use of these drugs . Vancomycin should be replaced by simpler drugs like Linizolid or Cotrimoxazole to preserve this useful antibiotic and prolong its therapeutic usefulness.en_US
dc.identifier.citationPavani Gandham, Kommula Vani Madhavi, Mudaliar Jyothi lakshmi G. Bacteriological profile and multidrug resistance patterns of blood culture isolates in a teaching hospital in South India. National Journal of Integrated Research in Medicine. 2012 Jul-Aug; 3(3): 55-59.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/152170
dc.language.isoenen_US
dc.source.urihttps://www.scopemed.org/?mno=23408en_US
dc.subjectAndhra Pradeshen_US
dc.subjectBacteriological Profileen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectSepticaemiaen_US
dc.subjectBlood cultureen_US
dc.titleBacteriological profile and multidrug resistance patterns of blood culture isolates in a teaching hospital in South India.en_US
dc.typeArticleen_US
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