DNA binding and cytotoxicity of newly synthesized schiff base (z)-4-(((2-hydroxy phenyl) amino) (phenyl) methylene)-3-methyl-1-phenyl-1hpyrazol-5(4H)-one and its analogues.

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dc.contributor.authorGowri, M
dc.contributor.authorJayabalakrishnan, C
dc.date.accessioned2015-09-30T11:03:33Z
dc.date.available2015-09-30T11:03:33Z
dc.date.issued2012-10
dc.description.abstractA novel Schiff base (Z)-4-(((2-hydroxy phenyl)amino)(phenyl)methylene)-3-methyl-1-phenyl-1Hpyrazol- 5(4H)-one and its analogues were synthesized by condensation of 5-methyl-2-phenyl-4-substituted pyrazolin- 3-one with 2-amino phenol from alcoholic solution.Schiff base ligands arecharacterizedby IR, UV, NMR, elemental analysis and single crystal X- ray diffraction analysis. These potential ligands are subjected to DNA binding analysis against the Calf thymus DNA, their binding constant values were calculated and compared to the standard ruthenium intercalators. The cytotoxic natureof these Schiff base ligands was also studied with the human breast cancer cell line MCF-7 and their IC50 values were determined.en_US
dc.identifier.citationGowri M, Jayabalakrishnan C. DNA binding and cytotoxicity of newly synthesized schiff base (z)-4-(((2-hydroxy phenyl) amino) (phenyl) methylene)-3-methyl-1-phenyl-1hpyrazol-5(4H)-one and its analogues. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Oct-Dec; 3(4): 327-337.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163870
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?id=703en_US
dc.subjectPyrazole Schiff basesen_US
dc.subjectTautomerismen_US
dc.subjectDNA bindingen_US
dc.subjectCytotoxicityen_US
dc.subjectIC50en_US
dc.titleDNA binding and cytotoxicity of newly synthesized schiff base (z)-4-(((2-hydroxy phenyl) amino) (phenyl) methylene)-3-methyl-1-phenyl-1hpyrazol-5(4H)-one and its analogues.en_US
dc.typeArticleen_US
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