Methylation of E-cadherin and hMLH1 genes in Indian sporadic breast carcinomas.

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dc.contributor.authorViswanathan, Men_US
dc.contributor.authorSolomon, S P Ren_US
dc.contributor.authorTsuchida, Nen_US
dc.contributor.authorSelvam, G Sen_US
dc.contributor.authorShanmugam, Gen_US
dc.date.accessioned2009-05-28T11:53:54Z
dc.date.available2009-05-28T11:53:54Z
dc.date.issued2006-02-17en_US
dc.description.abstractHypermethylation of promoter regions leading to inactivation of tumor suppressor genes is a common event in the progression of several tumor types. We have employed a novel restriction digestion based multiplex PCR assay to analyse the methylation status of promoter regions of tumor suppressor genes (p16, hMLH1, MGMT and E-cadherin) in sporadic breast carcinomas of Indian women. The present results indicated the absence of hypermethylation in promoter region of p16 and MGMT genes. However, 6 of the 19 (31.6%) sporadic breast carcinomas showed hypermethylation in the promoters of two of the genes analysed; three in hMLH1 and another three in E-cad. Since our earlier studies have shown lack of genetic alterations such as missense mutations and deletions in the tumor associated genes-p16, ras and p14ARF in sporadic breast tumors, the epigenetic alterations of the two genes reported in the present study could be of interest and might be among the events in the genesis/progression of sporadic breast carcinomas.en_US
dc.description.affiliationDepartment of Biochemistry, Centre for Advanced Studies in Functional Genomics, School of Biological Sciences, Madurai Kamaraj University, India.en_US
dc.identifier.citationViswanathan M, Solomon SP, Tsuchida N, Selvam GS, Shanmugam G. Methylation of E-cadherin and hMLH1 genes in Indian sporadic breast carcinomas. Indian Journal of Experimental Biology. 2006 Feb; 44(2): 115-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57350
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6362/1/IJEB%2044%282%29%20115-119.pdfen_US
dc.subject.meshAdaptor Proteins, Signal Transducingen_US
dc.subject.meshBreast Neoplasms --geneticsen_US
dc.subject.meshCadherins --geneticsen_US
dc.subject.meshCarrier Proteins --geneticsen_US
dc.subject.meshDNA Methylationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshGenes, p16en_US
dc.subject.meshGenes, rasen_US
dc.subject.meshHumansen_US
dc.subject.meshNuclear Proteins --geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshTumor Markers, Biological --analysisen_US
dc.subject.meshTumor Suppressor Protein p14ARF --geneticsen_US
dc.titleMethylation of E-cadherin and hMLH1 genes in Indian sporadic breast carcinomas.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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