In-vitro Anticancer and In silico Assessment of Oxalis corniculata Against Colorectal Cancer (HCT 116) Cell line

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dc.contributor.authorAnsari, Saif MSen_US
dc.contributor.authorPrakash, Veeruen_US
dc.contributor.authorA, Sushmaen_US
dc.contributor.authorRao, K. P.en_US
dc.contributor.authorAhmed, Danishen_US
dc.contributor.authorKhan, Ibrahimen_US
dc.contributor.authorLall, Alok M.en_US
dc.date.accessioned2024-09-24T08:59:15Z
dc.date.accessioned2024-09-24T11:51:23Z
dc.date.available2024-09-24T08:59:15Z
dc.date.available2024-09-24T11:51:23Z
dc.date.issued2024-06
dc.description.abstractColorectal cancer is the third most frequently diagnosed cancer in both genders and the fourth foremost cause in respect to cancer-associated mortality. The metastasis mechanism of colorectal cancer shows that it gradually developed in the form of polyps under granular cells in the large intestine, which damages blood and lymph vessels. At present, chemotherapy and surgery are the major clinical approaches in treatment. Therefore, developing novel and effective drugs are requiring use of natural derivative compounds, a potent and significant effect in restricting the progression of colorectal cancer (CRC). The present research investigates the in vitro anticancer properties of various extracts of plant Oxalis corniculata counter cell viability of CRC cell line (HCT116) using an MTT assay. In silico docking studies of hexadecanoic acid were performed with cytochrome P450CYP17A1 protein (3RUK) to predict potential inhibitors and druglikeness as potential CRC inhibitors using ADME profiling adhered to five rule of Lipinski. The finding indicated the extracts of the Oxalis corniculata have anticancer and anti-proliferative activity. The cell cytotoxic observed against chloroform extract exhibited the highest inhibition against the HCT116 cell line, following ethanol and aqueous extract. The determined IC50 values for the ethanol, aqueous, and chloroform extracts were 53.94±1.29 µg/ml, 61.85±0.43 µg/ml, and 47.34±1.24 µg/ml, respectively The in silico molecular docking result shows that n-hexadecanoic acid compound was found to be effective against 3RUK protein associated with CRC. Therefore, the finding suggests Oxalis corniculata plants could be used to formulate potential therapeutic drugs for the development of anticancer agents.en_US
dc.identifier.affiliationsDepartment of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bio-engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bio-engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bio-engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bio-engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, Indiaen_US
dc.identifier.citationAnsari Saif MS, Prakash Veeru, A Sushma, Rao K. P., Ahmed Danish, Khan Ibrahim, Lall Alok M. . In-vitro Anticancer and In silico Assessment of Oxalis corniculata Against Colorectal Cancer (HCT 116) Cell line . International Journal of Pharmaceutical Sciences and Drug Research . 2024 May; 16(3): 350-358en_US
dc.identifier.issn0975–248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231635
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2024.160306en_US
dc.subjectOxalis corniculataen_US
dc.subjectcolorectal canceren_US
dc.subjectn-hexadecanoic aciden_US
dc.subjectmolecular dockingen_US
dc.subjectCytochrome P450CYP17A1en_US
dc.subject3RUKen_US
dc.subjectADMEen_US
dc.subjectcytotoxicityen_US
dc.subjectMTTen_US
dc.titleIn-vitro Anticancer and In silico Assessment of Oxalis corniculata Against Colorectal Cancer (HCT 116) Cell lineen_US
dc.typeJournal Articleen_US
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