Primary tumor lymphangiogenesis in oral squamous cell carcinoma with N0 neck is the key determinant of its therapeutics

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dc.contributor.authorTandon, Ankitaen_US
dc.contributor.authorSandhya, Kumarien_US
dc.contributor.authorSingh, Narendra N.en_US
dc.contributor.authorKumar, Amiten_US
dc.date.accessioned2025-08-13T11:40:47Z
dc.date.available2025-08-13T11:40:47Z
dc.date.issued2025-06
dc.description.abstractBackground: Vascular Endothelial Growth Factor?C (VEGF?C) plays a criticalrole in tumor growth and invasion through lymphangiogenesis and helps to identifythe variability of lymphatic potential of oral squamous cell carcinoma (OSCC)cases with or without lymph node metastasis. Materials and Methods: A total of65 cases of OSCC were included. The clinical details were obtained from patientrecords. The cases were grouped as N0 versus any N categories. All the caseswere immunohistochemically evaluated for VEGF?C within the primary tumorusing a standard protocol. An average of 5 lymph nodes were dissected fromall neck dissection specimens and were evaluated histopathologically. The dataobtained were statistically evaluated at 95% confidence interval and P ? 0.05.Results: 100% cases in our study showed VEGF?C immunopositivity. Theimmunoreactivity increased linearly with advancing grades. A total of 31 outof 40 N0 OSCC revealed score 2 (26%–50%) of VEGF?C immunoreactivity.Eighteen cases were false negative clinically. Conclusion: Recognition oflocoregional spread may empower clinicians for correct therapeutic decisionsin N0 versus any N case.en_US
dc.identifier.affiliationsDepartment of Oral Pathology, Microbiology, and Forensic Odontology, Dental College, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Anatomy, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology, Microbiology, and Forensic Odontology, Dental College, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Lab Medicine, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.citationTandon Ankita, Sandhya Kumari, Singh Narendra N., Kumar Amit. Primary tumor lymphangiogenesis in oral squamous cell carcinoma with N0 neck is the key determinant of its therapeutics. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 267-272en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253952
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_189_24en_US
dc.subjectLymph nodesen_US
dc.subjectlymphangiogenesisen_US
dc.subjectoral squamous cell carcinomaen_US
dc.subjectROCen_US
dc.subjectVEGF?Cen_US
dc.titlePrimary tumor lymphangiogenesis in oral squamous cell carcinoma with N0 neck is the key determinant of its therapeuticsen_US
dc.typeJournal Articleen_US
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