Primary tumor lymphangiogenesis in oral squamous cell carcinoma with N0 neck is the key determinant of its therapeutics
No Thumbnail Available
Date
2025-06
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
Background: Vascular Endothelial Growth Factor?C (VEGF?C) plays a criticalrole in tumor growth and invasion through lymphangiogenesis and helps to identifythe variability of lymphatic potential of oral squamous cell carcinoma (OSCC)cases with or without lymph node metastasis. Materials and Methods: A total of65 cases of OSCC were included. The clinical details were obtained from patientrecords. The cases were grouped as N0 versus any N categories. All the caseswere immunohistochemically evaluated for VEGF?C within the primary tumorusing a standard protocol. An average of 5 lymph nodes were dissected fromall neck dissection specimens and were evaluated histopathologically. The dataobtained were statistically evaluated at 95% confidence interval and P ? 0.05.Results: 100% cases in our study showed VEGF?C immunopositivity. Theimmunoreactivity increased linearly with advancing grades. A total of 31 outof 40 N0 OSCC revealed score 2 (26%–50%) of VEGF?C immunoreactivity.Eighteen cases were false negative clinically. Conclusion: Recognition oflocoregional spread may empower clinicians for correct therapeutic decisionsin N0 versus any N case.
Description
Keywords
Lymph nodes, lymphangiogenesis, oral squamous cell carcinoma, ROC, VEGF?C
Citation
Tandon Ankita, Sandhya Kumari, Singh Narendra N., Kumar Amit. Primary tumor lymphangiogenesis in oral squamous cell carcinoma with N0 neck is the key determinant of its therapeutics. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 267-272