Anti-idiotype antibodies: an alternative approach to tumor immunotherapy.

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dc.contributor.authorRaychaudhuri, Sen_US
dc.date.accessioned2009-05-28T12:46:50Z
dc.date.available2009-05-28T12:46:50Z
dc.date.issued1989-08-01en_US
dc.description39 references.en_US
dc.description.abstractStudies presented in this paper examined the tumor-specific cellular and humoral immunity induced by anti-idiotype antibodies (Ab2s) 2F10 and 3A4. A panel of Ab2s was made against a monoclonal anti-L1210/GZL lymphoma, 11C1. The Ab2s were screened for their ability to block 11C1 binding to tumor, to induce tumor-specific DTH and CTL responses and to induce an anti-tumor humoral response. Two Ab2s, 2F10 and 3A4, were found to have similar fine specificity and to induce similar cellular and humoral responses. These were then examined for their ability to elicit tumor-protective immunity. Only preimmunization with 2F10 Ab2 protected animals from live tumor challenge, and in this paper the possible causes of this difference in otherwise similar Ab2s is discussed.en_US
dc.identifier.citationRaychaudhuri S. Anti-idiotype antibodies: an alternative approach to tumor immunotherapy. Indian Journal of Experimental Biology. 1989 Aug; 27(8): 671-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58543
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Anti-Idiotypic --therapeutic useen_US
dc.subject.meshLymphocytes --immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred DBAen_US
dc.subject.meshNeoplasms --therapyen_US
dc.titleAnti-idiotype antibodies: an alternative approach to tumor immunotherapy.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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