Patho-epidemiology of cancer corpus uteri in Karachi South '1995-1997'.

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dc.contributor.authorBhurgri, Yasminen_US
dc.contributor.authorNazir, Kauseren_US
dc.contributor.authorShaheen, Yasmeenen_US
dc.contributor.authorUsman, Ahmeden_US
dc.contributor.authorFaridi, Naveenen_US
dc.contributor.authorBhurgri, Hadien_US
dc.contributor.authorMalik, Jawaiden_US
dc.contributor.authorBashir, Imtiazen_US
dc.contributor.authorBhurgri, Asifen_US
dc.contributor.authorHasan, Sheema Hen_US
dc.contributor.authorKayani, Nailaen_US
dc.contributor.authorZaidi, S H Men_US
dc.date.accessioned2009-05-27T17:52:09Z
dc.date.available2009-05-27T17:52:09Z
dc.date.issued2007-10-12en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractAIM: To provide demographics and pathology of cancer of the uterine corpus in Karachi. METHODOLOGY: Data for 66 incident cases of cancer corpus uteri, ICD-10 category C54-5 registered at the Karachi Cancer Registry, for Karachi South, during a 3 year period, 1st January, 1995 to 31st December 1997 were reviewed. RESULTS: Cancer uterine corpus (1995-97) was the sixth most common malignancy, following breast, oral cavity, ovary, esophagus and cervix. The age standardized incidence rate (ASR) world and crude incidence rate (CIR) per 100,000 were 6.4 (4.73 to 8.01) and 2.9 (2.18 to 3.57). The mean age was 53.7 years (SD 15.6; range 6-90 years). Fifty eight cases were endometrial carcinoma with ASR world and CIR per 100,000 of 5.77 (4.20 to 7.33) and 2.53 (1.88 to 3.18) respectively. Sarcomas comprised 6% of the cases. Approximately a third of the females (28.8%) were below 50 years of age. The age-specific curves showed a gradual increase from the fourth till the seventh decade, followed by an actual apparent decrease in risk after 70 years. Peak incidence was observed in the 65-69 year age group. Presenting symptoms were post-menopausal bleeding (86.4%) and purulent discharge (4%). Associated pathologies included adenomyosis, adenomatous hyperplasia (12% each) or leiomyoma (8%). Associated clinical conditions were diabetes mellitus and hypertension (4% each). The majority of the cases presented as well differentiated (39.4%), localized (59.1%) lesions. CONCLUSION: The incidence of cancer corpus uteri in Karachi South reflects a moderate risk population, predominantly middle aged with a higher socio-economic status. On the average the malignancy is observed a decade earlier then reported elsewhere. This calls for in-depth investigation of risk factors and identification of underlying etiology.en_US
dc.description.affiliationPathology & Microbiology Department, Agakhan University, Stadium Road, Karachi, Pakistan. bhurgri@cyber.net.pken_US
dc.identifier.citationBhurgri Y, Nazir K, Shaheen Y, Usman A, Faridi N, Bhurgri H, Malik J, Bashir I, Bhurgri A, Hasan SH, Kayani N, Zaidi SH. Patho-epidemiology of cancer corpus uteri in Karachi South '1995-1997'. Asian Pacific Journal of Cancer Prevention. 2007 Oct-Dec; 8(4): 489-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38056
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdenocarcinoma --epidemiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPakistan --epidemiologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSarcoma --epidemiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshUterine Cervical Neoplasms --epidemiologyen_US
dc.subject.meshYoung Adulten_US
dc.titlePatho-epidemiology of cancer corpus uteri in Karachi South '1995-1997'.en_US
dc.typeJournal Articleen_US
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