Evaluation of Retinal Nerve Fiber Layer Thickness in Patients having Pseudoexfoliation Syndrome

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dc.contributor.authorShahid, Men_US
dc.contributor.authorGupta, Ren_US
dc.contributor.authorHassan, A.en_US
dc.date.accessioned2025-05-12T08:15:08Z
dc.date.available2025-05-12T08:15:08Z
dc.date.issued2024-08
dc.description.abstractBackground: Pseudoexfoliation syndrome (PEX) is a systemic disorder and is characterized by a progressive chronic deposition and accumulation of extracellular grayish-white material in several organs including the eye. PEX can lead to a variety of intraocular problems that affect the eyes, particularly the lens and the trabecular meshwork. PEX also leads to structural changes in the retinal nerve fiber layer (RNFL) that can be detected by optical coherence tomography (OCT). Aims and Objectives: The aims and objectives of the study are to compare mean RNFL thickness in patients having PEX with normal age-matched controls using spectral domain OCT (SD-OCT). Materials and Methods: This case–control study was conducted at the Department of Ophthalmology, ASCOMS, Jammu, for 6 months on 88 eyes divided into two groups of 44 subjects each (Group A – subjects with PEX and normal intraocular pressure [IOP] and Group B – subjects with no evidence of ocular pathologies). Complete history and comprehensive ophthalmic examination were carried out in each subject. Statistical analysis of the data was done using the Statistical Packages for the Social Sciences version 19.0. Results: In both groups, the majority of the participants were in the age group 61–70 years old, and male patients outnumbered female patients in both groups. There was no significant difference in IOP in both groups. Statistically significant differences were detected between the two groups for mean average RNFL thickness (P = 0.019) and mean RNFL thickness in the inferior quadrant (P = 0.014). Conclusion: The patients having PEX with normal IOP and other visual fields have thin RNFL as compared to healthy age- matched controls.en_US
dc.identifier.affiliationsPost-Graduate Student, Department of Ophthalmology, ASCOMS and Hospital, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Ophthalmology, ASCOMS and Hospital, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsPost-Graduate Student, Department of Ophthalmology, ASCOMS and Hospital, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.citationShahid M, Gupta R, Hassan A. . Evaluation of Retinal Nerve Fiber Layer Thickness in Patients having Pseudoexfoliation Syndrome. International Journal of Scientific Study. 2024 Aug; 12(5): 61-64en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246965
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber5en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_aug_24_oa03_-_2024.pdfen_US
dc.subjectIntraocular problemsen_US
dc.subjectPseudoexfoliation syndromeen_US
dc.subjectSystemic disorderen_US
dc.titleEvaluation of Retinal Nerve Fiber Layer Thickness in Patients having Pseudoexfoliation Syndromeen_US
dc.typeJournal Articleen_US
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