Evaluation of Retinal Nerve Fiber Layer Thickness in Patients having Pseudoexfoliation Syndrome
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Date
2024-08
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International Research Organization for Life & Health Sciences
Abstract
Background: Pseudoexfoliation syndrome (PEX) is a systemic disorder and is characterized by a progressive chronic deposition and accumulation of extracellular grayish-white material in several organs including the eye. PEX can lead to a variety of intraocular problems that affect the eyes, particularly the lens and the trabecular meshwork. PEX also leads to structural changes in the retinal nerve fiber layer (RNFL) that can be detected by optical coherence tomography (OCT). Aims and Objectives: The aims and objectives of the study are to compare mean RNFL thickness in patients having PEX with normal age-matched controls using spectral domain OCT (SD-OCT). Materials and Methods: This case–control study was conducted at the Department of Ophthalmology, ASCOMS, Jammu, for 6 months on 88 eyes divided into two groups of 44 subjects each (Group A – subjects with PEX and normal intraocular pressure [IOP] and Group B – subjects with no evidence of ocular pathologies). Complete history and comprehensive ophthalmic examination were carried out in each subject. Statistical analysis of the data was done using the Statistical Packages for the Social Sciences version 19.0. Results: In both groups, the majority of the participants were in the age group 61–70 years old, and male patients outnumbered female patients in both groups. There was no significant difference in IOP in both groups. Statistically significant differences were detected between the two groups for mean average RNFL thickness (P = 0.019) and mean RNFL thickness in the inferior quadrant (P = 0.014). Conclusion: The patients having PEX with normal IOP and other visual fields have thin RNFL as compared to healthy age- matched controls.
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Keywords
Intraocular problems, Pseudoexfoliation syndrome, Systemic disorder
Citation
Shahid M, Gupta R, Hassan A. . Evaluation of Retinal Nerve Fiber Layer Thickness in Patients having Pseudoexfoliation Syndrome. International Journal of Scientific Study. 2024 Aug; 12(5): 61-64