Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking.

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dc.contributor.authorYoshida, Kanaen_US
dc.contributor.authorOsawa, Kayoen_US
dc.contributor.authorKasahara, Mayumien_US
dc.contributor.authorMiyaishi, Aikoen_US
dc.contributor.authorNakanishi, Keikoen_US
dc.contributor.authorHayamizu, Saorien_US
dc.contributor.authorOsawa, Yasunorien_US
dc.contributor.authorTsutou, Akimitsuen_US
dc.contributor.authorTabuchi, Yohikien_US
dc.contributor.authorShimada, Etsujien_US
dc.contributor.authorTanaka, Kenichien_US
dc.contributor.authorYamamoto, Masahiroen_US
dc.contributor.authorTakahashi, Juroen_US
dc.date.accessioned2009-05-27T17:32:37Z
dc.date.available2009-05-27T17:32:37Z
dc.date.issued2007-07-28en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractWe investigated CYP1A1*2A, CYP1A1*2C, CYP1A2*1C, CYP1A2*1F, GSTM1 and NAT2 gene polymorphisms, involving enzymes which metabolize many carcinogens, with reference to colorectal cancer risk. The distribution of these genotypes was not associated with risk overall. However, the CYP1A1*2A T/C genotype showed a significant association with colorectal cancer risk in never-smokers (odds ratio [OR], 3.06; 95% confidence interval [95% CI], 1.11-8.40; p = 0.030). The risk of the NAT2 rapid genotype in never-smokers was also statistically significantly increased (OR, 5.38; 95%CI, 1.80-16.1; p = 0.003). Furthermore, the joint effects of NAT2 rapid plus other genotypes were associated with colorectal cancer overall (OR, 3.12; 95%CI, 1.15-8.51; p = 0.026, for NAT2 rapid plus combined CYP1A1*2C Ile/Val and Val/Val, OR, 3.25; 95%CI, 1.09-9.74; p = 0.035, for NAT2 rapid plus CYP1A2*1C G/G, and OR, 4.20; 95%CI, 1.09-16.1; p = 0.037, for NAT2 rapid plus GSTM1 null, respectively). In never-smokers, the joint effects of NAT2 rapid plus other genotypes were remarkable (OR, 15.9; 95%CI, 1.87-135.8; p = 0.011, for NAT2 rapid plus combined CYP1A1*2A T/C and C/C, OR, 5.71; 95%CI, 1.49-21.9; p = 0.011, for NAT2 rapid plus combined CYP1A1*2C Ile/Val and Val/Val, and OR, 9.14; 95%CI, 2.05-40.7; p = 0.004, for NAT2 rapid plus CYP1A2*1F A/A, respectively). The joint effect of CYP1A2*1F A/A plus CYP1A2*1C G/G genotypes was also increased in never-smokers (OR, 6.16; 95%CI, 1.26-30.1; p = 0.025). Our findings suggest that the CYP1A1*2A T/C and NAT2 rapid genotypes is associated with colorectal cancer susceptibility without smoking exposure. These results also indicate that the NAT2 in combination with CYP1A1*2C, CYP1A2*1C, or GSTM1 genotypes may strongly confer susceptibility to colorectal cancer. In particular, the combination of NAT2 plus CYP1A1*2A, CYP1A1*2C, or CYP1A2*1F genotypes, and that of CYP1A2*1F plus CYP1A2*1C genotype may define a group of persons who are genetically susceptible to colorectal cancer in never smokers.en_US
dc.description.affiliationFaculty of Health Sciences, Kobe University Graduate School of Medicine, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan.en_US
dc.identifier.citationYoshida K, Osawa K, Kasahara M, Miyaishi A, Nakanishi K, Hayamizu S, Osawa Y, Tsutou A, Tabuchi Y, Shimada E, Tanaka K, Yamamoto M, Takahashi J. Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. Asian Pacific Journal of Cancer Prevention. 2007 Jul-Sep; 8(3): 438-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37369
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAgeden_US
dc.subject.meshArylamine N-Acetyltransferase --geneticsen_US
dc.subject.meshAsian Continental Ancestry Group --geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshColorectal Neoplasms --epidemiologyen_US
dc.subject.meshCytochrome P-450 CYP1A1 --geneticsen_US
dc.subject.meshCytochrome P-450 CYP1A2 --geneticsen_US
dc.subject.meshCytochrome P-450 Enzyme System --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshGlutathione Transferase --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshJapan --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshRisken_US
dc.subject.meshSmoking --epidemiologyen_US
dc.titleAssociation of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking.en_US
dc.typeJournal Articleen_US
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