Effect of the aqueous extract of African mistletoe, Tapinanthus sessilifolius (P. Beauv) van Tiegh leaf on gastrointestinal muscle activity.

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dc.contributor.authorTarfa, F Den_US
dc.contributor.authorAmos, Sen_US
dc.contributor.authorTemple, V Jen_US
dc.contributor.authorBinda, Len_US
dc.contributor.authorEmeje, Men_US
dc.contributor.authorObodozie, Oen_US
dc.contributor.authorWambebe, Cen_US
dc.contributor.authorGamaniel, Ken_US
dc.date.accessioned2009-05-28T15:13:57Z
dc.date.available2009-05-28T15:13:57Z
dc.date.issued2002-05-08en_US
dc.description.abstractEffects of the aqueous extract of T. sessilifolius on the gastrointestinal muscle were investigated on smooth muscle preparations isolated from rabbit jejunum, guinea pig ileum and on gastrointestinal transit in mice. Elemental analysis of the extract was also carried out. The aqueous extract of T. sessilifolius evoked a concentration dependent contraction of the rabbit jejunum and guinea pig ileum. The contractions evoked by the extract were not attenuated either by atropine or mepyramine, but they were completely blocked by verapamil. The elemental analysis revealed the presence of Mg, Zn, Fe, Cu, and very high concentration of Ca. The intraperitoneal LD50 in mice was found to be 1500 mg/kg. The aqueous extract of T. sessilifoliius possesses active components that may be mediating the observed biological activity through calcium mobilization.en_US
dc.description.affiliationNational Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki Abuja, Nigeria.en_US
dc.identifier.citationTarfa FD, Amos S, Temple VJ, Binda L, Emeje M, Obodozie O, Wambebe C, Gamaniel K. Effect of the aqueous extract of African mistletoe, Tapinanthus sessilifolius (P. Beauv) van Tiegh leaf on gastrointestinal muscle activity. Indian Journal of Experimental Biology. 2002 May; 40(5): 571-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61724
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Transit --drug effectsen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleum --drug effectsen_US
dc.subject.meshJejunum --drug effectsen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMistletoe --chemistryen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlant Leaves --chemistryen_US
dc.subject.meshRabbitsen_US
dc.titleEffect of the aqueous extract of African mistletoe, Tapinanthus sessilifolius (P. Beauv) van Tiegh leaf on gastrointestinal muscle activity.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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