Synthetic Bone Substitutes in Combination with Growth Factors for Maxillary Sinus Floor Augmentation: A Mini-review.

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dc.contributor.authorNacopoulos, Cleopatra C
dc.contributor.authorDontas, Ismene
dc.contributor.authorChronopoulos, Efstathios
dc.contributor.authorKhaldi, Lubna
dc.contributor.authorVesala, Anna Maria
dc.contributor.authorTriantafyllopoulos, Ioannis K
dc.contributor.authorPapaioannou, Nikolaos
dc.date.accessioned2016-12-27T07:49:25Z
dc.date.available2016-12-27T07:49:25Z
dc.date.issued2015
dc.description.abstractObjective: Growth factors have been applied in maxillary sinus augmentation with clinically successful results. The purpose of this article is to evaluate the effectiveness of growth factors in combination with various synthetic scaffolds. Methods and Materials: A systematic review of studies examining the effects of synthetic materials in combination with growth factors were performed. Results: Twelve (1 human and 11 animal) studies were eligible for inclusion. Due to the great heterogeneity of the studies regarding design, materials and outcomes, a meta-analysis was not performed. The majority of the studies show a reduction in healing time and enhancement of bone formation within the subantral environment. Bone Morphogenetic Protein-2 and GDF-5 were the two most common osteoinductive factors studied, showing a significant effect on new bone formation. Moreover, initial outcomes of trials with stem cells genetic transformation, that results in increased production of growth factors, are positive and justify further research. Conclusion: The incorporation of growth factors into the synthetic scaffold may be beneficial regarding the healing process.en_US
dc.identifier.citationNacopoulos Cleopatra C, Dontas Ismene, Chronopoulos Efstathios, Khaldi Lubna, Vesala Anna Maria, Triantafyllopoulos Ioannis K, Papaioannou Nikolaos. Synthetic Bone Substitutes in Combination with Growth Factors for Maxillary Sinus Floor Augmentation: A Mini-review. British Journal of Medicine and Medical Research. 2015; 7(12): 1026-1034.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/180531
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/metrics/8863en_US
dc.subjectSinus augmentationen_US
dc.subjectsynthetic materialsen_US
dc.subjectPRFen_US
dc.subjectgrowth factorsen_US
dc.titleSynthetic Bone Substitutes in Combination with Growth Factors for Maxillary Sinus Floor Augmentation: A Mini-review.en_US
dc.typeArticleen_US
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